1.Shon Booker, et al. Prmts inhibitors. WO2022132914A2022-06-23. Related Tags: buy AMG-193 | purchase AMG-193 | AMG-193 cost | order AMG-193 | AMG-193 chemical structure | AMG-193 in vitro | AMG-193 formula | AMG-193 molecular weight...
Insights into the binding mode of AMG 193 were elucidated by the crystal structure of AMG 193 bound to the MTA-PRMT5 complex. AMG 193 activity is enriched in MTAP-null cells in vitro, as illustrated in the HCT116 isogenic pair; AMG 193 is ~40X selective for MTAP-null cells (IC50 =...