AMG 592 is an investigational IL-2 mutein designed to expand Treg more selectively than recombinant IL-2 (aldesleukin). In a phase 1, double-blind, placebo (PBO)-controlled first-in-human (FIH) study, we investigated the safety and tolerability of AMG 592 and pharmacodynamic (PD) effects ...
Background AMG 592 is an investigational IL-2 mutein designed for greater regulatory T-cell (Treg) selectivity and longer half-life than recombinant IL-2 (aldesleukin). We investigated the tolerability of AMG 592 and its effects on expansion of Tregs, conventional effector T-cells (Tcon), and...
AMG 592 is an investigational IL-2 mutein designed for greater Treg selectivity and longer half-life compared with recombinant IL-2 (aldesleukin). In preclinical studies and a phase 1, double-blind, placebo (PBO)-controlled first-in-human (FIH) study, we investigated the safety and ...