V. (2004) Alternative splicing of mRNA of mouse in- terleukin-4 and interleukin-6. Cytokine 28, 190 -196.Yatsenko O P, Filipenko M L, Khrapov E A, et al. Alterna- tive splicing of mRNA of mouse interleukin-4 and interleukin- 6. Cytokine, 2004, 28(4-5): 190~196...
【答案】在mRNA前体的剪接过程中,参加剪接的外显子可以不按其线性次序剪接,内含子也可以不 被切除而保留,即一个外显子或内含子是否出现在成熟mRNA中是可以选择的,这种剪接方式称为选择性 剪接。此外,不同的启动子或不同的poly A加尾位点的选择,也可看作选择性剪接。选择性剪接的方式主 要有4种:(1)拼接产物...
可变剪接(Alternative Splicing, AS,也称选择性剪接)是一种受调控的过程,通过以不同的组合连接和跳跃外显子,多个蛋白质由单个基因编码。 在人类中,可变剪接增强了基因组编码的蛋白质的多样性,这占多外显子基因的 95%。 在《急性PM2.5净化对认知功能的影响及其潜在机制》研究中,可变剪接(Alternative Splicing, AS)...
Alternative splicing is a process that enables a messenger RNA (mRNA) to direct synthesis of different protein variants (isoforms) that may have different cellular functions or properties. It occurs by rearranging the pattern of intron and exon elements that are joined by splicing to alter the mRN...
【答案】：选择性剪切是一个基因转录产物在不同的发育阶段、分化细胞和生理状态下，通过不同的剪切方式可以得到不同的mRNA和翻译产物。方式有①剪接产物缺失一个或几个外显子；②剪接产物保留一个或几个内含子；③外显子中存在3'或5'剪接点，从而部分缺失该外显子；④内含子中存在3'或5'剪接点，...
(a) Identification of RNA-binding proteins involved in MALT1 splicing by RNA interference. Jurkat T cells were transfected with smart pool siRNA against the depicted proteins and the ratio MALT1A/B mRNA was analysed by qPCR. (b) Knockdown of hnRNP U after transfection of three independent siRN...
Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of gene control in humans. It provides cells with the opportuni... CJ David,JL Manley - 《Genes Dev》 被引量: 1013发表: 2010年 Positive control of pre-mRNA splicing in vitro Positive control of the ...
Pre-mRNA alternative splicing is a major source of proteomic and functional diversity . In humans, ~95% of multi-exon genes are subjected to alternative splicing , and splicing defects are associated with a variety of gene...
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes, particularly in regulating cell numbers. In this ...
- 《Journal of Virology》 被引量: 267发表: 1988年 Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene Alternative polyadenylation and splicing of mRNA transcribed from the human Sin 1 gene. Gene. 2004; 339 :17–23. doi: 10.1016/j.gene.2004.07.001. [ ......