Davie, Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma cells. J Biol Chem, 2015. 290(1): p. 310-24.Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in ...
The spliceosome must assemble onto each intron to catalyse its excision, and this assembly is controlled by a large number of pre-mRNA-binding proteins. Alternative splicing can produce many different kinds of insertions and deletions in the final mature mRNA, and these changes can drastically alter...
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes, particularly in regulating cell numbers. In this r...
Pre-mRNA alternative splicing is a major source of proteomic and functional diversity . In humans, ~95% of multi-exon genes are subjected to alternative splicing , and splicing defects are associated with a variety of gene...
【答案】在mRNA前体的剪接过程中,参加剪接的外显子可以不按其线性次序剪接,内含子也可以不 被切除而保留,即一个外显子或内含子是否出现在成熟mRNA中是可以选择的,这种剪接方式称为选择性 剪接。此外,不同的启动子或不同的poly A加尾位点的选择,也可看作选择性剪接。选择性剪接的方式主 要有4种:(1)拼接产物...
Alternative splicing of pre-mRNA plays an important role in immune cell development and regulation of immune activity through yielding diverse transcriptional isoforms to supplement the function of limited genes associated with the immune reaction. In addition, multiple factors have been identified as ...
To understand the biological impact of alternative pre-mRNA splicing, it is vital to know which exons are involved, what protein domains they encode, and how the translated isoforms differ. Therefore, we developed a computational pipeline (RiboSplitter) focused on functional effect prediction. It bu...
mRNA剪接类型(mRNA Splicing Types) 新转录的 RNA 转录本称为前mRNA(pre-mRNA),尚未准备好翻译成真核生物。相反,它必须转化为成熟的 mRNA(messenger RNA,信使 RNA),才能翻译成蛋白质合成。它必须经过各种处理步骤才能成熟。这包括以下内容: 在RNA 的 5′ 末端添加一个帽子,称为 5’ 帽。
Alternative Pre-Mrna Splicing 作者:Stamm, Stefan 编/Smith, Chris 编/L?hrmann, Reinhard 编 出版社:Wiley-VCH 出版年:2012-2 页数:660 定价:$ 99.95 ISBN:9783527326068 豆瓣评分 评价人数不足 评价: 写笔记 写书评 加入购书单 分享到 + 加入购书单...
【答案】：选择性剪切是一个基因转录产物在不同的发育阶段、分化细胞和生理状态下，通过不同的剪切方式可以得到不同的mRNA和翻译产物。方式有①剪接产物缺失一个或几个外显子；②剪接产物保留一个或几个内含子；③外显子中存在3'或5'剪接点，从而部分缺失该外显子；④内含子中存在3'或5'剪接点，...