Furthermore, a more fundamental understanding of alterations in the activation of various pathways, such as the polyol and lactate pathway, could hold the key to improving outcomes following TBI.Gribnau, Annerixtvan Zuylen, Mark L.Coles, Jonathan P....
Thus, decreased pyruvate kinase activity in PKM2-expressing cells allows PEP-dependent histidine phosphorylation of PGAM1 and may provide an alternate glycolytic pathway that decouples adenosine triphosphate production from PEP-mediated phosphotransfer, allowing for the high rate of glycolysis to support ...
Thus, decreased pyruvate kinase activity in PKM2-expressing cells allows PEP-dependent histidine phosphorylation of PGAM1 and may provide an alternate glycolytic pathway that decouples adenosine triphosphate production from PEP-mediated phosphotransfer, allowing for the high rate of glycolysis to support ...
Revealingly, these five alternative pathways pivot on acetyl-coenzyme A, the turntable of metabolism, demanding a gluconeogenic pathway starting from acetyl-coenzyme A and CO(2). It appears that the formation of an activated acetic acid from inorganic carbon represents the initial step toward ...
The book closely analyzes the cofactors used to augment the function of defective enzymes and the compounds that are able to utilize an alternative pathway in order to avoid the consequences of the metabolic block present in the patient. Among other therapies, the authors discuss the use of zinc...
1995. A role for active oxygen species as second messengers in the induction of alternative oxidase gene expression in Petunia hybrida cells. FEBS Lett. 368: 339–342. Google Scholar Wagner, A.M., Krab, K. 1995. The alternative respiration pathway in plants: role and regulation. Physiology...
During tumor progression, cancer cells may experience nutrient deprivation and hypoxia, due to overgrowth. As compared with normal cells, tumor cells preferentially metabolize glucose through the aerobic glycolysis pathway, for which some genes encoding enzymes are susceptible to alternative splicing. The ...
As the main pathway to degrade superfluous proteins and damaged organelles, macro-autophagy is featured with the formation of isolation membranes, autophagosomes and autolysosomes during the process [7]. The term “autophagy”is generally used as the synonym with macro-autophagy. Isolation membranes ...
During tumor progression, cancer cells may experience nutrient deprivation and hypoxia, due to overgrowth. As compared with normal cells, tumor cells preferentially metabolize glucose through the aerobic glycolysis pathway, for which some genes encoding enzymes are susceptible to alternative splicing. The ...
(SO3−) and then sulphide (S2−). Sulphide is then incorporated into homocysteine. Homocysteine lies at the crossroads between the transsulfuration pathway, which results in the production of cysteine (and, further on, glutathione), and the methyl cycle, which leads to methionine and SAM ...