Su XW, Broach JR, Connor JR, Gerhard GS, Simmons Z. Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research. Muscle Nerve. 2014; 49 :786–803. doi: 10.1002/mus.24198. [ Cross Ref ]Su XW, Broach JR, Connor JR, Gerhard GS, Simmons Z (...
“In this era of extensive genetic testing, it has become increasingly likely that variants in genes will be detected that are not directly linked to the primary diagnosis,” Grassano said in a meeting news release. “These insights will help inform future research on diagnosing and treating this...
Because of the severe symptoms and high mortality rate of ALS, Medicare has special rules in place to provide health insurance coverage for people impacted by this disease. ALS is a progressive disease, and there is no cure. But the disease can be slowed through medication, and treatments are...
Becoming educated and informed about ALS is a good first step. Here you’ll find general information about the disease, including diagnosis, symptoms, and causes. Get informed Personal experiences It helps to know others have been where you are now. Here’s a collection of our columnists’ wo...
, Muscular Dystrophy Association, Les Turner ALS Foundation, PGA Tour, Gates Ventures, and Bari Lipp Foundation. This work was also supported, in part, by grants from the National Institutes of Health and the MIT-GSK Gertrude B. Elion Research Fellowship Program for Drug Discovery and Disease....
Amyotrophic lateral sclerosis (ALS) is a progressive and uniformly fatal neurodegenerative disease. A plethora of genetic factors have been identified that drive the degeneration of motor neurons in ALS, increase susceptibility to the disease or influence the rate of its progression. Emerging themes inc...
A study found that genetic mutations associated with amyotrophic lateral sclerosis (ALS) lead to problems with the function and transport of mitochondria, cellular structures needed for energy production, early in the disease course, before abnormal protein clumps are formed. “We show that the nerve...
The J. David Gladstone Institutes received support from National Center for Research Resources Grant RR18928. Author information Author notes Maria Armakola and Matthew J Higgins: These authors contributed equally to this work. Robert V Farese and Aaron D Gitler: These authors jointly directed this...
Genomenon Genomic Landscapes provide the complete picture of a disease or pathway with a unique 2-pronged approach AI-Driven Genomenon’s Computational Intelligence organizes and indexes all medical evidence and makes it easily searchable Expertly Curated ...
Organoids provide a suitable biological platform for assessing dynamic sequences of human-specific cellular events, especially those relevant to neurodegenerative disease research, in which many cell types are now implicated in pathogenesis. However, the timing and cell-specific characteristics of molecular...