alpha-Thalassemia (alpha-thal) encompasses a spectrum of mutations including deletion and point mutations on the alpha-globin chains that is characterized by a reduction or complete absence of alpha-globin genes. Most of the alpha-thal cases are deletions involving one (alpha(+)) or both (alpha...
In the individuals heterozygous for an α-chain abnormality, the product of a single α-gene could be isolated from that of the three others using the differing physicochemical properties of the mutant haemoglobins. In the special situation of a double heterozygosity for an α-chain abnormality, ...
4) alpha-globin gene α珠蛋白基因 1. The objective of study was to investigate the effect of liposomal transfection of antisense oligodeoxynucleotide (ASON) on alpha-globin gene expression and proliferation of K562 cells, to explore the new way of gene therapy in β-thalassemia. 本研究查明...
The aim of this study was to determine the common alpha globin gene deletions among individuals with hypochromic microcytic anemia in Kermanshah province.Methods: Following the initial evaluation, 92 patients (47 women and 45 men) were found as microcytic hypochromic [MCV 80 fl and MCH 27 pg] ...
Nucleotide sequence analysis of a recombinant cDNA for a duck alpha-globin gene indicates a gene with novel features and evolutionary history. The duck alpha-globin double-stranded cDNA, treated with S1 nuclease and tailed with poly(dC), was inserted into the Pst I restriction endonuclease site ...
Waye J S;Eng B;Chui D H;.Identification of an extensive zeta-alpha globin gene deletion in a Chinese individual.Br J Haematol.1992.378-380Waye JS,Eng B,Chui DH.Identification of an extensive zeta-alpha globin gene deletion in a Chinese individual.British Journal of Haematology. 1992...
… an individual totally lacking the specific gene responsible for making an essential part of hemoglobin called the alpha globin chain.The New York Times compare beta globin Browse Nearby Entries Alphagan alpha globin alpha globulin See all Nearby Words Cite this Entry Style “Alpha globin....
α-Thalassemia commonly results from deletions or point mutations in one or both α-globin genes located on chromosome 16p13.3 giving rise to complex and variable genotypes and phenotypes. Rarely, unusual non-deletion defects or atypical deletions down-regulate the expression of the α-globin gene....
A novel α-globin gene arrangement in man We report the isolation of a cluster of four α-like globin genes from a bacteriophage λ library of human DNA ( Lawn et al., 1978). Analysis of the cloned DNA confirms the linkage arrangement of the two adult α-globin genes (α1 and α.....
We describe the characterization of an alpha+-thalassaemia determinant as a result of a transition of G-->A of the donor splice consensus site sequence of the first intron of the alpha1-globin gene (alpha1IVS I-1). The mutation was found in combination with the South-East Asian alpha0-...