The α-actinins are a family of actin-binding proteins that are structurally related todystrophin. Of the four members in the α-actinin family, only the sarcomericisoformsα-actinin-2 and α-actinin-3 (Actn3) have been shown to bind dystrophin and other Z-disk associated proteins at thes...
Myotilin, a Novel Sarcomeric Protein with Two Ig-like Domains, is Encoded by a Candidate Gene for Limb-Girdle Muscular Dystrophy The striated muscle sarcomeres are highly organized structures composed of actin (thin) and myosin (thick) filaments that slide past each other during cont... P Salmi...
Sarcomeric alpha - actinin defective in vinculin-binding cause Z-line expansion and nemaline-like body formation in cultured chick myotubes[ J]. Exp Cell Res ,2009,315 (5) :748-759.Zhang ZQ,Bish LT,Holtzer H,et al.Sarcomeric alpha-actinindefective in vinculin-binding cause Z-line expansion...
Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin. EMBO J. 17:1614-1624.Young, P., Ferguson, C., Banuelos, S., and Gautel, M. (1998). Molecular structure of the sarcomeric Z-disk: two types of titin ...
Synaptopodin 2-like protein (SYNPO2L) is localized in the sarcomere of cardiomyocytes and is involved in heart morphogenesis. However, the molecular function of SYNPO2L in the heart is not fully understood. We investigated the interaction of SYNPO2L with sarcomeric α-actinin and actin filaments ...
Overexpression of GFP-C terminus deleted annexin A6 in cardiomyocytes showed aggregate like appearance in the cytoplasm. Double immunofluorescent staining of cardiomyocytes with anti annexin A6 and anti sarcomeric α-actinin antibodies showed perfect co-localization of these two proteins with annexin A6 ...