Described are new non-steroidal drugs for treatment of benign prostatic hyperplasia and other disorders mediated by high 5-alpha reductase activity, high dihydrotestosterone levels, and other conditions of hyperandrogenic stimulation, of the formula: wherein A, D, E, X, R, R min , R sec , ...
As a result of this study, the inhibition of this enzyme has become a pharmacological strategy for the design and synthesis of new antiandrogenic drugs. The advent of finasteride 8 (Fig. (4)) a 5alpha-reductase inhibitor has grately alleviated the symptoms associated with benign prostatic ...
The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate To perform the first evaluation of the effects of the 5-alpha-reductase inhibitor class of drugs on cancer histopathologic features at radical prostatectom... KA Iczkowski,...
中文别名 刺芒柄花素(485-72-3);芒柄花素;7-羟基-4-甲氧异苯酮;7-羟基-3-(4-甲氧苯基)色酮;7-羟基-4'-甲氧基异黄酮;生原禅宁B;芒柄花黄素;7-羟基-4`-甲氧基异黄酮 英文别名 Formononetin, Testosterone 5alpha-reductase inhibitor(CAS:485-72-3);Formononetin CAS号 485-72-3 SMILES OC1...
Purpose: To compare the clinical therapeutic efficacy of finasteride and dutasteride as 5-alpha reductase inhibitor (5-ARI) in the medical treatment of benign prostate hyperplasia. Materials and Methods: From July 2007 to July 2010, 354 benign prostatic hyperplasia patients with co...
Prostate cancer patients can benef i t from5-alpha-reductase inhibitor treatment: ameta-analysisTuo Deng 1 , *, Xueming Lin 2 , *, Xiaolu Duan 1 , Zihao He 1 , Zhijian Zhao 1and Guohua Zeng 11 Department of Urology and Guangdong Key Laboratory of Urology, The First Aff i liated Hosp...
Finasteride, a 5 alpha-reductase inhibitor, was investigated for its effects on fertility in male rats as part of its preclinical safety assessment. Studie... David Wise, L.,DH Minsker,MA Cukierski,... - 《Reproductive Toxicology》 被引量: 117发表: 1991年 Effect of finasteride, a 5 alpha...
Date Apr. 14, 1994Described are new 17 beta -carboxanilides of 4-aza-5 alpha -androstan-3-ones and related compounds of structural formula I: <IMAGE> I and the use of such compounds as 5 alpha -reductase inhibitors for treatment of benign prostatic hyperplasia acne, seborrhea, female ...
reductase inhibitor (5-ARI) or an anticholinergic. We also excluded patients who had comorbidities such as prostate cancer (ICD-10,C61), bladder cancer (C679), neurogenic bladder (N319), urinary tract infection (N390), urethral stricture (N350, N358, N359), ureteral stone (N201, N202)...
Disclosed herein are topical compositions of 5-α reductase inhibitors, such as dutasteride or finasteride, or a pharmaceutically acceptable salt, ester, or derivative thereof and th