Cao M,Liu Z,Jia X, et al.Detection of a-globin gene deletions using denaturing high-performance liquid chromatography and multiplex ligation-dependent probe amplification. Journal of Clinical Laboratory Analysis . 2011Detection of a-globin gene deletions using denaturing high-perform...
In order to determine whether any heterogeneity exists in the human α-globin chain, i.e. whether the products of the duplicated genes are identical, we have determined the total sequence of 14 α-globin chains: seven of these were abnormal, while six were normal chains from the same ...
别名 HBA1, Hemoglobin a, HBA2, Alpha-globin, Alpha globin 计算分子量 15 kDa 观测分子量 14-16 kDa, 27 kDa GenBank蛋白编号 BC050661 基因名称 HBA1 Gene ID (NCBI) 3039 RRID AB_3670874 偶联类型 Unconjugated 形式 Liquid 纯化方式 Protein A purfication UNIPROT ID P69905 储存缓冲液 PBS with...
alpha globin noun variantsalsoα-globin :the chain ofhemoglobinthat is designated alpha and that when deficient or defective causes a form of anemia known asalpha-thalassemia … an individual totally lacking the specific gene responsible for making an essential part of hemoglobin called thealpha globi...
Since the Iranian populaion is a mixture of different ethnic groups, frequency and distribution of globin mutations in various regions of the country need to be clarified. The aim of this study was to determine the common alpha globin gene deletions among individuals with hypochromic microcytic ...
Waye J S;Eng B;Chui D H;.Identification of an extensive zeta-alpha globin gene deletion in a Chinese individual.Br J Haematol.1992.378-380Waye JS,Eng B,Chui DH.Identification of an extensive zeta-alpha globin gene deletion in a Chinese individual.British Journal of Haematology. 1992...
Nucleotide sequence analysis of a recombinant cDNA for a duck alpha-globin gene indicates a gene with novel features and evolutionary history. The duck alpha-globin double-stranded cDNA, treated with S1 nuclease and tailed with poly(dC), was inserted into the Pst I restriction endonuclease site ...
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slight...
5). Clinically, this model is most similar to a trans-two alpha gene deletion, in which only one of the two copies of the alpha globin gene is lost. However, this genetic deletion only affects alpha globin expression in the endothelium. Endothelial-specific deletion was confirmed, with no ...
We describe the characterization of an alpha+-thalassaemia determinant as a result of a transition of G-->A of the donor splice consensus site sequence of the first intron of the alpha1-globin gene (alpha1IVS I-1). The mutation was found in combination with the South-East Asian alpha0-...