A DNA construct comprising a DNA sequence encoding a polypeptide having 伪-galactosidase activity, wherein the DNA sequence a) encodes a polypeptide comprising the amino acid sequence shown in the appended SEQ ID No. 3, or b) is an analogue of the DNA sequence of a), which i) hybridizes...
The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having α-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected ...
Alpha-galactosidase (Agalsidase) enzyme. Cause of Fabry's disease. Administered as enzyme replacement therapy. Atoms shown as spheres with conventional color coding: hydrogen (white) etc,站酷海洛,一站式正版视觉内容平台,站酷旗下品牌.授权内容包含正版商业
Function theory α-galactosidase is a kind of polysaccharide anti-nutrient factor that exists in some botanic seeds, whose content ratio is highest in beans seed while lowest in grain seed. Poultry has no endogenous enzyme to digest α-galactosidase but pigs can partially ferment it with the aid...
The effect of Alpha- galactosidase enzyme with and without avizyme 1502 on performance of broilers fed diets based on corn and soybean meal[J]. Int J Pouh Sci, 2005, 4(12): 920-937.The effect of alpha-galactosidase enzyme with and without Avizyme 1502 on performance of broilers fed ...
Human lysosomal alpha-galactosidase A (alpha-Gal A) was stably overexpressed in CHO cells and its biosynthesis and targeting were investigated. Clone AGA5.3-1000Mx, which was the highest enzyme overexpressor, produced intracellular alpha-Gal A levels of 20,900 U/mg (approximately 100 micrograms of...
α-Galactosidase B is an α-N-acetylgalactosaminidase. Deficiencies in α-galactosidase B are responsible for Schindler disease. Native GLA has a molecular weight of 101 kDa and represents a homodimer with 49 kDa subunits. The enzyme is heavily glycosylated with asparagine-linked high mannose ...
Alpha galactosidase is an enzyme used in digesting sugars in vegetables and grains. If a person's body doesn't produce alpha...
- D - Galactose - galactohydrolase (E.C.3.2.1.22), commonly referred to as -galactosidase, catalyzes the hydrolysis of -galactosidic linkages in oligo-saccharide such as raffinose, melibiose, stachyose and verbascose, polysaccharides like galactomannans, and glycoconjugates such as glycoproteins an...
Fabry disease is an X-linked genetic disorder caused by a deficiency of 伪-galactosidase A (GLA) activity. As enzyme replacement therapy (ERT) involving re... T Togawa,T Kodama,T Suzuki,... - 《Molecular Genetics & Metabolism》 被引量: 203发表: 2010年 ...