A major target of the adrenergic system is the hippocampus, a region that is critical for learning and memory. Recent studies suggest alpha-1A adrenergic receptors (α-ARs) may regulate neurogenesis and neuronal differentiation. Our understanding of the function of α-ARs is limited due to a ...
alpha receptor, alpha-adrenergic receptor, alpha-adrenoceptor - receptors postulated to exist on nerve cell membranes of the sympathetic nervous system in order to explain the specificity of certain agents that affect only some sympathetic activities (such as vasoconstriction and relaxation of intestinal ...
It is unclear why alpha(1D)-adrenergic receptors (alpha(1D)-ARs) play a critical role in the mediation of peripheral vascular resistance and blood pressure in situ but function inefficiently when studied in vitro. The present study examined the causes for these inconsistencies in native alpha(1...
adrenergic drugphr. 肾上腺素药 相似单词 adrenergicadj. 肾上腺素能的 receptorn. 1.【生】感受器;受体 alphan. 希腊字母的第一个字母,最初,开端 anti adrenergic抗肾上腺素药 benzotrichloride, alpha , alpha , alpha【化】 三氯甲苯; 次苄基三氯 ...
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family...
Receptors Adrenergic receptors Adrenoceptors (ARs) are members of the GPCR superfamily, interfacing between the sympathetic nervous system and the cardiovascular system, with integral roles in the rapid regulation of myocardial function. In heart failure (HF), chronic catecholamine-dependent stimulation of...
Alpha-adrenergic receptor 1a Alpha-adrenergic receptor 1c alpha-adrenergic receptors alpha-adrenergic receptors alpha-adrenergic receptors alpha-adrenoceptor alpha-adrenoceptor antagonist alpha-adrenoceptor antagonist alpha-adrenoceptor blocking drugs Alpha-adrenoreceptor antagonists ...
Selective blockade of alpha-1 adrenergic receptors was confirmed by the marked reduction in the pressor response to intravenous infusion of phenylephrine hydrochloride (−80 ± 15%, P = 0.001 versus pre-prazosin). The blockade significantly decreased the standard deviation of the systolic ...
As a result, alpha and beta adrenergic receptors were further subdivided into alpha-1, alpha-2, alpha-1/alpha-2 subtypes. Functional differences between alpha-1 and alpha-2 receptors have been recognized, and compounds, which exhibit selective binding between these two subtypes have been developed...
Functional differences between α1 and β2 receptors have been recognized, and compounds which exhibit selective binding between these two subtypes have been developed. Thus, in WO 92/0073, the selective ability of the R(+) enantiomer of terazosin to selectively bind to adrenergic receptors of ...