Alpha2 adrenergic receptor (A2AR) antagonist modulates EEG theta-band and gamma band in healthy individualsAliment Pharmacol Ther 28, 344–352 Background Symptom improvement in irritable bowel syndrome (IBS) treatment trials varies widely, with only 50–70% of patients qualifying as responders. ...
alpha receptor,alpha-adrenoceptor sympathetic nervous system- originates in the thoracic regions of the spinal cord; opposes physiological effects of the parasympathetic: reduces digestive secretions; speeds the heart; contracts blood vessels receptor- a cellular structure that is postulated to exist in ...
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The depressive effect of clonidine on the flexor reflex was reversed by the selective alpha 2-receptor antagonist, atipamezole (20 micrograms, i.t.), ... XJ Xu,MJC Puke,Z Wiesenfeld-Hallin - 《Pain》 被引量: 189发表: 1992年 Actions of α2 adrenoceptor ligands at α2A and 5-HT1A re...
Modulation of acoustic startle and its PPI by the α2A-AR subtype was investigated with mice lacking the α2A-AR (α2A-KO) and their wild-type (WT) controls, without drugs and after administration of the α2-AR agonist dexmedetomidine or the antagonist atipamezole. The interaction of D-...
Alpha adrenergic receptoragonists are sympathomimetic agents because they tend to mimic the effects seen after stimulation of the sympathetic arm of the autonomic nervous system. Conversely, alpha adrenergic receptor antagonist are sympatholytic because the block such actions. ...
The selective alpha 2-adrenoceptor antagonist CH-38083, however, did not modify the apomorphine inhibition of [3H]Glu release or dopa accumulation, and the alpha 2-adrenoceptor agonist xylazine did not alter tritium efflux from striatum preloaded with [3H]Glu. These findings suggest that release ...
1. The ability of the putative, selective post-junctional alpha 2-adrenoceptor antagonist, SK&F 104078 to antagonize the effects of structurally-diverse agonists at pre-junctional alpha 2-adrenoceptors in the guinea-pig ileum and rat vas deferens in vitro and in the rat heart in vivo, and at...
In a further single-blind placebo controlled study in three of these volunteers, the alpha 2-adrenoreceptor antagonist RX 781094 at a dose of 0.1 mg/kg i.v. reversed the miosis induced by i.v. clonidine 0.2 mg. At a dose of 0.05 mg/kg the miosis was partially reversed....
If an agonist occupies the receptor, a biological process such as enzyme activation, ion influx or efflux across membranes, or production or utilization of energy is then triggered. If an antagonist binds to the receptor, it does not cause a measurable response, but rather blocks the effects ...