ALPHA-1 ANTITRYPSIN PHENOTYPE AND GENOTYPE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)autologous transfusionallogeneic transfusionhip arthroplastyimmunomodulationhumoral immune systemcellular immune systempostoperative infectionIn five studies comparing various forms of storage of autologous blood the...
The finding is recorded of typical a1-antitrypsin globules, confirmed by immunofluorescence and immunoperoxidase methods, in the hepatocytes of a patient shown to have a normal serum antitrypsin level and normal phenotype (TiM) for a1-antitrypsin. The identification of such globules can no longer be...
Diagnosis is based on the analysis of the AAT genotype and phenotype. The measurement of the AAT serum level is useful as screening test. Liver biopsy is not necessary to establish the diagnosis. Therapy for AAT-related liver disease is supportive, a specific therapy is not available. AATD is...
alpha 1-AntitrypsinGenetic MarkersHepatitis B AntibodiesRiskPhenotypeFemaleMaleThe BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as ...
A case history of a 16-year-old boy with and an intermediate deficiency of (MZ phenotype) is presented. Previous reports have suggested that may be associated with the Z variant of antitrypsin and either a severe or intermediate antitrypsin deficiency. The present case is unusual because of the...
Liver injury in PiZZ α1-antitrypsin (α1-AT) deficiency probably results from toxic effects of the abnormal α1-AT molecule accumulating within the ER of liver cells. However, only 12–15% of individuals with this same genotype develops liver disease. Therefore, we predicted that other ...
R. 2010 Discordant alpha-1 antitrypsin phenotype and genotype results in a liver transplant patient. Clin. Chim. Acta 411, 1146-1148.Hackbarth, J. S., L. J. Tostrud, K. M. Rumilla, M. J. Krowka, and M. R. Snyder. 2010. Discordant alpha-1 antitrypsin phenotype and genotype ...
Alpha-1-antitrypsin MZ phenotype and cryptogenic chronic liver disease in adults. Digestion . 1983;27:100–104.Vecchio FM, Fabiano A, Orsini G, Ragusa D, Massi G. Alpha- 1-antitrypsin MZ phenotype and cryptogenic chronic liver disease in adults. Digestion. 1983;27:100-4....
Alpha-1- antitrypsin (AAT) and its stimulation in the liver of PiMZ phenotype individuals. A "recruitment-secretory block" ("R-SB") phenomenon. Liver. 1984;4(5):325-37.Callea F, Fevery J, Massi G, Lievens C, de Groote J, Desmet VJ. Alpha- 1-antitrypsin (AAT) and its stimulation...
Alpha-1 Antitrypsin Deficiency SZ Phenotype Associated With Necrotizing Panniculitis and Ground Glass Opacities on Chest CTCongenital Disorder Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Common manifestations of Alpha-1...