α1,4- N -acetylglucosaminyltransferase (α4GnT) is a glycosyltransferase that mediates transfer of GlcNAc from UDP-GlcNAc to βGal residues with α1,4-linkage preferentially present in O -glycans forming GlcNAcα1→4Galβ→R, and cDNA encoding α4GnT was isolated from a human stomach cDNA...
Alpha-1,4-N-Acetylglucosaminyltransferase 4, also known as A4GNT is a 45 kDa glycoprotein, member of the glycosyltransferase 32 family of proteins. A4GNT catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. A4GNT is a single-pass type II membrane protein ...
A cyclodextrin glycosyltransferase (CGTase) was successfully used for the preparation of benzyl and phenyl α-d-glucopyranoside derivatives.3062 The production of glycosides with the CGTase of Brevibacterium species has been patented.3063 Using an alkalophilic CGTase in a slurry containing 13% sucrose ...
the mechanism of action of 4-α-glycosyltransferase (4α-Gtase) needs to be further elucidated. In addition, gene modification of 4α-Gtase can be carried out to improve its specificity and activity. The large molecular ring in LR-CDs is relatively flexible, which means that some guest mol...
Chatterjee SK, Bhattacharya M, Barlow JJ (1979) Glycosyltransferase and glycosidase activities in ovarian cancer patients. Cancer Res 39:1943–1951 Chen D, Liu JL, Liu Y, Zhu J, Wang SW (2011) Lack of an association between -308G>A polymorphism of the TNF-α gene and liver cirrhosis ri...
alpha1,4-N-acetylglucosaminyltransferase (alpha4GnT) is a glycosyltransferase that forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R, specifically present in gastric gland mucous cell-type mucin. Recently, we molecularly cloned human alpha4GnT and showed that alpha4GnT is expressed in the ...
The enzyme is an exceptional glycosyltransferase in that it can use both type I and type II oligosaccharides as acceptor substrates to generate subterminal Fuc alpha(1,4)- and Fuc alpha(1,3)-linkages, respectively, in a manner analogous to the human Lewis blood group fucosyltransferase. ...
WbwB is the final glycosyltransferase in the biosynthesis pathway of the ECO104 antigen repeating unit. This work contributes to knowledge of the biosynthesis of bacterial virulence factors.Czuchry, DianaSzarek, Walter A.Brockhausen, InkaQueens Univ Dept Biomed &Glycoconjugate journal...
Janecek S.Parallelβ/α-barrels ofα-amylase,cyclodextrin glycosyltransferase and oligo-1,6-glucosidase versus the barrel ofβ-amylase:evolutionary distance is a reflection of unrelated sequences. FEBS Letters . 1994Janecek, S. (1994) Parallel beta/alpha-barrels of alpha-amylase, cyclodextrin ...
Alpha-cyclodextrin (α-CD) production, using cyclodextrin glycosyltransferase (CGTase) from Klebsiella pneumoniae AS-22, was investigated in the presence of various complexing agents using raw wheat starch and dextrin as substrates. The addition of many alcohols resulted in increased conversion of both ...