Alms1 人类同源基因 ALMS1品系描述 该小鼠Alms1 携带c.3802-3812缺失突变。 应用领域:Alstrom综合征(Alström syndrome,ALMS),阿耳斯特雷姆综合征 *使用本品系发表的文献需注明: Alms1-del(c.3802-3812) mice (Cat. NO. NM-KI-220067) were purchased from Shanghai Model Organisms Center, Inc.. 相...
图6. C57BL/6-Alms1-del小鼠在21周时观察到严重的脂肪肝表型,包括脂肪变性、炎症、脂质沉积和纤维化。 (7)炎症、纤维化相关标志物表达 图7. C57BL/6-Alms1-del小鼠中炎症、纤维化相关标志物表达水平显著升高。数据以Mean±SD展示,n=5。使用unpaired two-tailed Student's t-test方法进行统计学分析。**,p...
16 weeks old B6-Alms1-del mice were treated with vehicle and semaglutide for 5 weeks, respectively. Our results indicate that semaglutide lead to benefit on metabolic syndrome, including body weight control, improvement in hyperglycemia, hyperlipidemia, liver injury and hepatic steatosis. In ...
*使用本品系发表的文献需注明: Alms1-del(c.3802-3812) mice (Cat. NO. NM-KI-220067) were purchased from Shanghai Model Organisms Center, Inc.. 相关品系 Alms1-del(c.3802-3812) 品系名:C57BL/6Smoc-Alms1em(delc.3802-3812)Smoc 品系状态:精子冻存 | 目录号:NM-KI-220067 Alms1-Flox 品系...
Because AS was considered, genetic analysis of the ALMS1 gene was performed and a homozygous pathogenic (Class-II) mutation c.3132_3133delAC/ p.Gln1045ValfsTer2 was detected in the exon 8 region of the ALMS1 gene. His mother was heterozygous carrier of the same mutation. Conclusion: A ...