Research Article 195 The allosteric regulation of pyruvate kinase by fructose-1,6bisphosphate 来自 Citeseer 喜欢 0 阅读量: 36 作者:MS Jurica,A Mesecar,PJ Heath,W Shi,T Nowak,BL Stoddard 摘要: Background: Yeast pyruvate kinase (PK) catalyzes the final step in glycolysis. The enzyme therefore...
octamer conformations. These results suggest that changes in the oligomeric state contribute to the allosteric regulation of TbGMPR by purine nucleotides. Discussion Here, we demonstrate the determination of the crystal structures ofT. bruceiGMPR; a protein that, unlike the GMPRs of host animals, ...
This enzyme is found in the glycolysis pathway and is composed of 4 subunits. What is the difference between competitive inhibition and allosteric regulation? Competitive inhibition is when a substance binds directly at the active site of an enzyme preventing it from binding the substrate. Allosteric...
6-bisphosphateGlycolysisAllosteric regulationAscites tumor cellMammary glandPhosphofructokinase (PFK) subunits and isozymes have been examined in ascites tumor cells... SMJ Aragón - 《Febs Letters》 被引量: 81发表: 1997年 Reaction of Ascaris suum phosphofructokinase with diethylpyrocarbonate. Inactivation ...
The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. Yeast pyruvate kinase (PK) catalyzes the final step in glycolysis. The enzyme therefore represents an important control point and is allosterically activat... MS Jurica,A Mesecar,PJ Heath,... - 《Structure》 被引量: ...
Allosteric regulation of phos- phofructokinase controls the emergence of glycolytic oscillations in isolated yeast cells. The FEBS jour- nal. 2014; 281(12):2784-93. doi: 10.1111/febs.12820 PMID: 24751218Gustavsson AK, van Niekerk DD, Adiels CB, Kooi B, Goksor M, Snoep JL. Allosteric ...
Phosphofructokinase-This is the most vital enzyme of Glycolysis. It works through Allosteric inhibition. It also regulates the hormones like insulin and glucagon in eukaryotes. Thus Allosteric regulation of enzymes takes part in several crucial biological reactions. ...
modulates regulation of phosphorylation by cGMP binding to GAF-A, and impacts affinity of the catalytic domain for vardenafil-based inhibitors[36, 49]. Site-directed mutagenesis of residues in GAF-A or in both GAFs compromises cGMP binding and causes a three- to four-fould increase in Kmof ...
When these cell types are activated, they fragment their mitochondria and shift to aerobic glycolysis70. Intriguingly, inhibition of Drp1, and other interventions that maintain oxidative phosphorylation, have been found to suppress the activation of pro-inflammatory immune cells and promote the anti-...
(CCM: glycolysis, gluconeogenesis, pentose phosphate pathway and TCA pathway) is critical in Mtb physiology and pathogenicity5,6,7. This is illustrated by the rapid regulation of glycolytic activity in response to changes in ATP levels, which explains the enhanced efficacy of drug combinations that...