I liked that Study.com broke things down and explained each topic clearly and in an easily accessible way. It saved time when preparing for exams. Recommended Lessons and Courses for You Related Lessons Related Courses Effect of pH on Enzyme Activity | Overview & Interaction Secretin Definiti...
2007. Intrinsic dynamics of enzymes in the unbound state and relation to allosteric regulation . Curr. Opin. Struct. Biol. 17 :633–640 10.1016/j.sbi... I Bahar,C Chennubhotla,D Tobi - 《Curr Opin Struct Biol》 被引量: 424发表: 2007年 Intrinsic dynamics of enzymes in the unbound sta...
One-carbon metabolism is regulated at several levels: via gene expression, posttranslational modification, subcellular compartmentalization, allosteric inhibition, and feedback regulation. In this review, we aim to inform the readers of relevant one-carbon metabolism regulation mechanisms and to bring ...
Strict correlation between this enzyme's gene expression, protein level and enzyme activity is not observed, thus confirming multilevel-regulation. In this context, besides post-translational modifications of proteins, we have to consider feedback of metabolic flow and allosteric regulation, alternative ...
The 3D-structures of (a) TEM-1 b-lactamase (PDB 1BTL) and (b) the b-lactamase encoded by the most probabilistic sequence at the GNCA node11 (PDB 4B88) are displayed. The residues for which the relaxation rates cannot be explained without including a conformational exchange contribution (...
These studies, along with those of James and Elizabeth Miller and their student Allan Conney [13], were among Table 2 Mechanisms of P450- related drug-drug interactions Perpetrator drug Inducer Inducer Competitive inhibitor Irreversible inhibitor Allosteric activator Effect on victim drug ...
Furthermore, unlike most other cysteine peptidases, the catalytic triad of cysteinyl peptidase DUBs is not usually in a 'functional' configuration, with allosteric regulation being required to render DUBs fully functional and processive. Such allosteric regulation can be substrate-mediated (for example,...
et al. Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase. Mol. Cell 44, 147–159 (2011). 217. Finley, D. Recognition and processing of ubiquitin- protein conjugates by the proteasome. Annu. Rev. Biochem. 78, 477–...
(Eriksson et al.2002). For a quick example, Fontes and Gilbert (2010) explained that calcium is pivotal for dockerin (a facet of most enzyme structures) stability and function, and in the presence of ethylenediaminetetraacetic acid (EDTA, a chelating agent), dockerins are unable to interact...
endo-cleavage could be observed in those non-degradative ub-chains by DUBs such as CYLD and AMSH-LP [42,43]. The positioning specificity could be explained based on DUB’s structure difference. USP14 encompasses a finger subdomain which contacts up to 40% of the distal ubiquitin and blocks...