P. Gomez-Martinez,M. Dessolin,F. Guibe,F. Albericio.Nu-Alloc temporary protection in solid-phase peptide synthesis the use of amine-borane complexes as allyl group scavengers.J. Chem. Soc. Perkin Trans. I. 1999Nα -Alloc temporary protection in solid-phase peptide synthesis. The use of ...
aThe N-Fmoc protecting group was removed with Et2NH and the corresponding free amine was coupled to N-alloc-(S-triphenylmethyl)-D-cysteine with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI) and HOBT in DMF and CH2Cl2 to yield the tripeptide 135 in good yield. N-Fmoc保护的小组去除了...
N上脱ALLOC NDMBA.pdf,View Online P Enantioselective total synthesis of vicenistatin, a novel E 20-membered macrocyclic lactam antitumor antibiotic R K I a a a a b N Yoshitaka Matsushima, Hiroaki Itoh, Takuya Nakayama, Sayo Horiuchi, Tadashi Eguchi and Ka
Enantioselectivetotalsynthesisofvicenistatin,anovel 20-memberedmacrocycliclactamantitumorantibiotic YoshitakaMatsushima, a HiroakiItoh, a TakuyaNakayama, a SayoHoriuchi, a TadashiEguchi b andKatsumiKakinuma* a a DepartmentofChemistry,TokyoInstituteofTechnology,O-okayama,Meguro-ku, Tokyo152-8551,Japan b Depart...
One cyclization method often used is the formation of a lactam bridge between an amine and a carboxylic acid. It is desirable to perform the cyclization on resin as opposed to in solution to avoid unwanted side reactions; therefore, a common strategy is to use –Alloc and –OAllyl protecting...