coprophila the X and X´ are distinguished not by a single allele but rather a series of alleles of varying potency, and that the difference between monogenic and digenic species is the ‘strength’ of the X´ chromosome. It is now known that the X´ in B. coprophila is ...
It chunks the genome into 1<<20 (~1 million) bases, encodes each variant into a 32 bit integer (with a supplemental table for those that can't fit due to large REF and/or ALT alleles). It uses the zip format, delta encoding and integer compression to create a compact and searchable...
chrysippus are present in the population studied on the campus of the University of Dar-es-Salaam. Forms chrysippus and dorippus (fig. 1) are common while the two forms with white hindwings, alcippus and albinus, are rare (Smith, 1973a). All the broods analysed here were obtained from ...
It is known that the relative costs of different alleles are environmentally dependent, but our results also demonstrate that the relative fitness of given alleles depends on which alleles are present in a given population, as previous pairwise comparisons of allele fitness do not exactly match (...
Higher plasma concentrations of rosuvastatin have been reported in very small groups of patients (n=3 to 5) who have two reduced function alleles of the gene that encodes OATP1B1 (SLCO1B1 521T > C). The frequency of this genotype (i.e., SLCO1B1 521 C/C) is generally lower than ...
Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population. Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as phenytoin, S-warfarin, tolbutamide, losartan, torasemide, and nonsteroidal......
The two multiplex PCRs amplified a total of 13 loci in the L genome and 13 loci in the R genome. Of these, 8 L loci and 12 R loci were polymorphic in the parents with 2–5 alleles each. All alleles were specific to either the L or the R genome. Four of the primer pairs amplif...
Infrequent methylation of CDKN2A(MTS1/p16) and rare mutation of both CDKN2A and CDKN2B(MTS2/p15) in primary astrocytic tumours. In a series of 46 glioblastomas, 16 anaplastic astrocytomas and eight astrocytomas, all tumours retaining one or both alleles of CDKN2A (48 tumours) and CD... ...
The fact that sexually antagonistic According to this hypothesis, the mutation of amn might alleles segregate in the population might select for a lead to a premature ecdysone release leading to the breakdown of the genetic correlation between the sexes, development of small adults. Our results are...
Favorable alleles increase in frequency more rapidly than expected for a neutral genetic scenario and further alter the allele frequencies of genomic variants near the beneficial mutation. The identification of signatures of selection has been carried out on several sheep breeds using genome-wide single...