Details the use of a sampling coverage method in estimating the total number of alleles. Presence of unequal allele frequencies in a population; Result of simulation studies; Details on possible applications of the model.Shu-Pang HuangWeir
This single-SNP model extends to multiple SNPs in a straightforward manner by using a vector of allelic dosages (Xi1, ⋯ , Xip) and genetic effects (β1, ⋯ , βp) instead of the scalar values above. Here, p represents the number of genetic variants in the cis-window...
The number of inflammatory markers in the blood, such as IL-18 and PTX3, was measured using the ELISA method (Shanghai Crystal Day Biotech Co., Ltd). The intra-assay and interassay coefficients of variation (CV) were less than 10% and 12%, respectively, for the IL-18 ELISA kit, ...
What is a population crash? What are the causes of ectopic pregnancies? What kind of impact would you assume if there are an especially high number of post-reproductive members in a population? Would this be beneficial, detrimental, or have no effect on the population? An ...
it is estimated that the actual total number of alleles at the 14 loci is 53, or an average of 3.79 per locus (1.96 per electromorph), and that electrophoresis apparently detects one-third of the variants, thus describing about 50% of the alleles at structural gene loci in the house mous...
A total of 741 patients and 686 controls were typed using polymerase chain reaction amplification of HLA-DPB alleles and subsequent sequence specific oligonucleotide by bridization. The frequency of HLA-DPB15O3O1 was found to be signifi cantly increased in white patients, compared with ethnically...
SCD also had a significant difference with PD and HC in T-tau/α-syn. MCI showed a similar tendency as SCD, but there was no statistical significance possibly due to the insufficient number of samples. Interestingly, T-tau/α-syn and P-tau181/α-syn appeared the statistical difference ...
Population genetic analysis of the collected Borrelia species points to an increase in B. afzelii and B. garinii populations. Conclusions Together, these findings indicate an increase in the total number of Borrelia-infected ticks, providing circumstantial evidence for an increase in the risk of ...
The assumptions on which the selection model we are considering is based are: (a) A population of diploid, sexually reproducing organisms with dis- crete generations is considered, with A1 and A2 being the alleles at the sex-linked locus. FITNESS ESTIMATION AT SEX-LINKED LOCI 149 (b) The ...
In children with atopic asthma, risk alleles in IL-13 (A–1512C and C–1112T) and IL-13Ra1 (A+1398G) showed increased total IgE (P=0.012, 0.015 and 0.017, respectively). Three-loci haplotype analysis for IL-13 showed that the haplotype composed of –1512C, –1112T and +2044A was...