ISG20 is a broad-spectrum antiviral protein capable of specifically degrading viral RNA. Here, we examine the different strategies developed by viruses to evade ISG20-mediated restriction, shedding light on how this exonuclease distinguishes between self and non-self RNAs, and highlighting the many ...
assess long non-coding RNAs, detect transcript variants (including SNPs and SNVs), study fusion transcripts, (re-)annotate model and non-model organisms, perform transcriptomics on archived biobank samples (FFPE material) The CORALL RNA-Seq Library Prep Kits enable fast and cost-efficient generatio...
用柱上DNA酶处理纯化的RNA,以有效去除DNA污染。根据RNA与离心柱的结合情况,纯化的RNA中可能含有也可能不含miRNA等小RNAs。对于纯化后的DNA,可选择性进行柱上RNA酶消化,因为在离心前的DNA和RNA分离步骤中RNA污染水平已达到zui低。 应用 尽管AllPrep DNA/RNA FFPE Kit已经过优化,可zui大程度上逆转福尔马林化学修饰,...
RNA plays a critical role in all aspect of life and errors in RNA cause diseases, many currently without cures. Therefore, it is the utmost important to have robust tools to see, study, and drug these RNAs. Lucerna, Inc. is an early-stage biotech company comprised of high caliber scienti...
Many methods exist for determining protein structures from cryogenic electron microscopy maps, but this remains challenging for RNA structures. Here we developed EMRNA, a method for accurate, automated determination of full-length all-atom RNA structures
Depletion of rRNA and globin mRNA frees up sequencing space for RNAs of interest (Fig. 6) and leads to a significant increase in gene detection (Fig 7 A and B). This workflow allows to study coding and non-coding RNAs of the blood, including mRNA, lncRNAs, snoRNAs, and snRNAs. For ...
AllPrep DNA/RNA FFPE Kit 从福尔马林固定、石蜡包埋的组织切片中同时纯化基因组DNA和总RNA(包括小RNAs) 使用小样本量即可获得大量纯化产物 在纯化同时,保持DNA和RNA的完整性 高效分离RNA和DNA 对同一FFPE样本进行全面的DNA和RNA分析 80234AllPrep DNA/RNA FFPE Kit (50)...
Most of the Human Genome Expresses Regulatory RNAs Johns Hopkins University, Baltimore 70.5 Miles from Solomons As part of the Department of Molecular Biology & Genetics Seminar Series, Professor John Mattick from the University of New South Wales will present on Regulatory RNAs in the Human Genom...
使用TRI 试剂从 LeukoLOCK™ 过滤器捕获的细胞中提取 RNA 的替代实验方案 Alternate Protocol: Isolation of Small RNAs Using the RiboPure™-Blood Kit 用于采集白细胞的血液成分分离方案 Fluorescently Labeling Long dsRNA with the Silencer™ siRNA ...
Production of canonical small interfering RNAs (siRNAs) Preparation of bioconjugates involving oligonucleotides Synthesis of siRNA with 2’-sugar moiety-modified nucleosides (2’-F, 2’-OMe, 2’-MOE) Synthesis of siRNA with locked nucleic acids (LNA) and bridged nucleic acid (BNA) ...