A new two-component alkylarylation of N-benzyl-N-(2-ethynylaryl)amides with alpha-bromoalkyl esters using visible light photoredox catalysis promoted by silver salts for producing substituted dibenzazepines is described. Employing alpha-bromoalkyl esters to form the alkyl carbon-centered radicals ...
In conclusion, we have developed a generic protocol for the intermolecular, regioselective,syn-alkylarylation of terminal alkynes with tertiary alkyl oxalates through a synergistic merger of photoredox and nickel catalysis. A one-pot, three-step sequence, involving radical addition, transition-metal-base...
Nonsteroidal anti-inflammatory drug derivatives (NSAIDs) are an important class of medications. Here we show a visible-light-promoted photoredox/nickel catalyzed approach to construct enantioenriched NSAIDs via a three-component alkyl arylation of acryla
ChemInform Abstract: Free‐Radical Cascade Alkylarylation of Alkenes with Simple Alkanes: Highly Efficient Access to Oxindoles via Selective (sp3)C&m... ChemInformFree-Radical Cascade Alkylarylation of Alkenes with Simple Alkanes:Highly Efficient Access to Oxindoles via Selective (sp3)C–H and (sp2...
ALKYLATIOIM, ACYLATION, AND ARYLATION PRODUCTS OF 1-CYANO-ISOTHIOCHROMANE1-Cyano-isothiochromane (1a) can be alkylated in position 1, using the carbanion that is formed from sodium amide, sodium hydride, or n-butyllithium. With methyl iodide or ethyl iodide 1c and 1d are formed; with 卤...
A general and atom-economical electrochemical dehydrogenative method for the intermolecular 1,2-alkylarylation of styrenes with malonates and nucleophilic N-heteroarenes (including indoles and pyrroles) has been developed. This transformation provides a regioselective route to construct highly valuable 1,1...
ChemInform Abstract: Arylation of Diethyl Alkylmalonates: Synthetic Route to Diethyl Alkyl(substituted Aryl)malonates with the Aid of Temporary Arene Complexation by the Cyclopentadienyliron Moiety.doi:10.1002/chin.198925127The title malonates, e.g. (IV), are prepared via nucleophilic substitution of ...
Intramolecular C−H Activation by Alkylpalladium(II) Complexes: Insights into the Mechanism of the Palladium-Catalyzed Arylation Reaction 来自 Wiley 喜欢 0 阅读量: 9 作者:Belén,Martín-Matute,Cristina,Mateo,Diego,J.,Cárdenas,Antonio,M.,Echavarren 摘要: The cyclization of ...
ChemInform Abstract: Gold‐Catalyzed Tuning of Reactivity in Allenes: 9‐endo Hydroarylation versus Formal 5‐exo Hydroalkylation.multi‐membered O,S‐heterocycles (O or S ring members)ring closure reactionscatalysis, phase‐transfer catalysis
Solvent-FreeBuchwald–Hartwig(Hetero)arylationofAnilines, Diarylamines,andDialkylaminesMediatedbyExpanded-Ring N-HeterocyclicCarbenePalladiumComplexes MaximA.Topchiy, [a,b] PavelB.Dzhevakov, [b] MargaritaS.Rubina, [b,c] OlegS.Morozov, [b] AndreyF.Asachenko, [b] andMikhailS.Nechaev* [b,c] Ab...