HistiocyticALK-positive histiocytosisKIF5B-ALKfusionCentral nervous systemActa Neuropathologica -doi:10.1007/s00401-019-02027-7Calixto-Hope G. LucasAhmed GilaniDavid A. SolomonXiayuan LiangArie PerrySpringer NatureActa Neuropathologica
A Case of Unicentric Castleman Disease and Langerhans Cell Histiocytosis: Two Entities in One Lymph Node Background: Castleman disease (CD) is a lymphoproliferative disorder and Langerhans cell histiocytosis (LCH) is a clonal disease of the monocyte-macrophage... X Liu,L Liu,L Zhang,... - ...
The lung nodules were diagnosed as ALK-positive histiocytosis (APH) carrying an EML4::ALK gene fusion, which microscopically displayed a mixed morphology of foamy cells, spindle cells, and Touton's giant cells. Immunohistochemistry showed expression of CD163, CD68, and ALK,...
The clinicopathological spectrum of ALK-positive histiocytosis is broader than originally described, and this entity is characterized by frequent presence of KIF5B-ALK gene fusion. We recommend that every unusual histiocytic proliferative disorder, especially disseminated lesions, be tested for ALK expression...
ALK-positive Histiocytosis (ALK-HSs) is a recently identified rare clinical entity characterized by tissue histiocytic alterations associated with ALK gene rearrangement. Clinical presentations can be solitary, multifocal, or systemic (involving multiple sites and organs). Due to lim...
We present two interesting cases of anaplastic lymphoma kinase (ALK)-positive histiocytosis in adults. The first was a 79-year-old woman with a 10-year history of a firm, violaceous, exophytic nodule on her right upper arm. It was asymptomatic, and stable in size and colour. It measured...
ALK-positive histiocytosisKIF5B-ALKBackground Since the first report in 2008 of cases of anaplastic lymphoma kinase (ALK)-positive histiocytosis, originally described as a systemic, self-limiting disease in infants, the range of ALK-positive histiocytosis has been expanded to include localized diseases...
ALK-positive histiocytosispediatricsFDG PET/CT.An 11-year-old girl presented with focal impaired awareness seizures. MRI brain demonstrated a T2 hyperintense cortical lesion in the left temporal lobe with surrounding vasogenic edema. 18F-FDG PET/CT was arranged to assess metabolic activity of the ...
ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibitiondoi:10.1182/blood.2021013338Paul KempsJennifer PicarsicBenjamin H DurhamJean Francois Emile
ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion.doi:10.1038/S41379-018-0168-6Kenneth Tou En ChangAmos Zhi En TayChik Hong KuickHuiyi ChenElizabeth AlgarNadine TaubenheimJanine Campbell