ALK-positive Histiocytosis (ALK-HSs) is a recently identified rare clinical entity characterized by tissue histiocytic alterations associated with ALK gene rearrangement. Clinical presentations can be solitary, multifocal, or systemic (involving multiple sites and organs). Due to lim...
An Anaplastic Lymphoma Kinase (ALK) Immunohistochemical Pitfall: ALK-positive Histiocytosis versus Angiomatoid Fibrous Histiocytoma In this case study, a cutaneous mass initially suspected as ALK-positive histiocytosis was found to be angiomatoid fibrous histiocytoma (AFH) with ALK ... J Chang,J ...
The study demonstrated intensely increased FDG uptake within the left temporal lobe lesion without evidence of hypermetabolic lesions elsewhere on the whole-body acquisition. The brain lesion was excised, and histopathology and molecular testing were consistent with ALK-positive histiocytosis. 展开 关键词...
定义:ALK阳性组织细胞增生症(ALK-positive histiocytosis)是一种缺乏高度细胞异型性的组织细胞肿瘤,以ALK(间变淋巴瘤激酶)免疫反应性为特征,通常是由于ALK基因重排引起的。 ICD-O编码 9750/3 ALK阳性组织细胞增生症 ICD-11编码 EK 92恶性潜能不确定的组织细胞增生症 相关术语 可接受:ALK相关组织细胞增生症,ALK重排...
ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases. Blood 2003;102:2642–2644. 14 Chan JK, Lamant L, Algar E, et al. ALK+ histiocytosis: a novel type of systemic histiocytic proliferative dis- order of early infancy. Blood 2008...
Many of these cases had been previously diagnosed as malignant histiocytosis. The neoplastic cells in ALCL express CD30 (Ki-1, Ber-H2) antigen and can be of T-cell, B-cell, or null phenotype. ALCL of B- or T-cell type is recognized in the revised Kiel classification.2 However, the ...
Case report: ALK-positive histiocytosis presented as bilateral synchronous breast masses with long-term remission on crizotinibdoi:10.3389/fmed.2023.1288849Yuhang ZhouHurtado-Castillo, MarisabelPandey, OmFrontiers in Medicine
RESULTS (IF A CASE STUDY ENTER NA). NA CONCLUSION. It is noteworthy that ALK-positive histiocytosis can occasionally present alongside features of a reactive process in the breast. Therefore, considering any history of prior surgery or trauma at the lesion site is crucial. However, we recommend...
In this case study, a cutaneous mass initially suspected as ALK-positive histiocytosis was found to be angiomatoid fibrous histiocytoma (AFH) with ALK expression, highlighting the potential diagnostic pitfall due to overlapping histomorphology and ALK expression. METHODS/CASE REPORT. A previously ...
Methods: We reported a case of ALK-positive histiocytosis with multisystem involvement. Together with a comprehensive literature review, the imaging characteristics of this disease in the nervous system were summarized. Results: A 3-year-old girl with abdominal pain and ambulation difficu...