Alder 烯反应(Alder-Ene Reaction) Alder 烯反应是带有烯丙基氢的烯烃(烯)与亲烯体发生化学反应,生成新的σ 键,烯基双键发生迁移,氢原子发生 1,5 位移,产物是双键移至烯丙基位置的取代烯烃。 此反应在1943年由库尔特·阿尔德发现,并以他的名字命名。 试剂: 路易斯酸 反应物: 含烯丙基氢的烯烃,亲烯体 产...
Alder 烯反应(Alder-Ene Reaction) Alder 烯反应是带有烯丙基氢的烯烃(烯)与亲烯体发生化学反应,生成新的σ 键,烯基双键发生迁移,氢原子发生 1,5 位移,产物是双键移至烯丙基位置的取代烯烃。 此反应在1943年由库尔特·阿尔德发现,并以他的名字命名。 试剂: 路易斯酸 反应物: 含烯丙基氢的烯烃,亲烯体 产...
Alder 烯反应(Alder-Ene Reaction) Alder 烯反应 Alder 烯反应是带有烯丙基氢的烯烃(烯)与亲烯体发生化学反应,生成新的σ 键,烯基双键发生迁移,氢原子发生 1,5 位移,产物是双键移至烯丙基位置的取代烯烃。 此反应在1943年由库尔特·阿尔德发现,并以他的名字命名。 试剂: 路易斯酸 反应物: 含烯丙基氢的烯...
The Alder–ene type reaction between alkenes and alkynes provides an efficient and atom-economic method for the construction of C-C bond, which has been widely employed in the synthesis of natural products and other functional molecules. The intramolecular enantioselective Alder-ene cycloisomerization r...
Alder烯反应(Alder Ene Reaction) 概要 烯烃和烯丙基化合物的六中心σ键迁移反应。通常,高温是必要条件,但Lewis酸以及过渡金属的条件下也能进行该反应。 使用烯烃替代物的亲双键羰基化合物试剂的羰基-烯反应(Prins反应)也十分有用。 基本文献 ・Alder. K. et al.Chem. Ber.1943,76, 27....
The reaction between an alkene of at least one allylic hydrogen (ene) and another unsaturated compound (i.e., enophile) to form a new olefinic compound with a new bond connecting the two unsaturated termini, and the allylic hydrogen is transferred to the enophile is generally known as Alder...
The reaction which was first reported by Trost and Lautens provided an efficient alternative to the thermal or Lewis acid catalyzed cycloisomerizations involving ene-type reaction. The IMAE cyclization of enynes and dienes has emerged as an important area and found significant applications in building...
5.2.2.1.2 Intramolecular type b Bäckvall, Córdova, and colleagues reported a heterogeneous copper-catalyzed Alder-Ene reaction of allenylamides 13 that gives pyrroles 14 and pyrrolines 15 depending on the solvent chosen. The mixed copper(I/II) nanoparticles are immobilized on aminopropyl-functio...
We have computationally explored the trend in reactivity of the Alder-ene reactions between propene and a series of seven enophiles using density functional theory at M06-2X/def2-TZVPP. The reaction barrier decreases along the enophiles in the order H2CCH2 > HCCH > H2CNH > H2CCH(COOCH3...
Here we report the discovery of two homologous groups of pericyclases that catalyse distinct reactions: one group catalyses an Alder-ene reaction that was, to our knowledge, previously unknown in biology; the second catalyses a stereoselective hetero-Diels–Alder reaction. Guided by computational ...