The double mutation M411V/T231A of EpiI reversed the periselectivity from the native hetero-Diels–Alder reaction (<5:95, 8:9) to the energetically disfavoured Alder-ene reaction (2:1, 8:9), although the enzymatic activity is only moderately decreased (Extended Data Fig. 9). In the ...
A variety of transition metals have been shown to catalyze both the inter- and intramolecular Alder-ene reactions. The unique reactivity of each metal is mirrored in the diversity of scaffolds accessible via the Alder-ene reaction. The synthetic importance of the ene reaction is evidenced by its...
A mild, thermal Alder—ene reaction of enallenes has been developed. The allenic double bond acts as the 'ene' and generates a carbon-carbon bond to an unactivated olefinic 'enophile' in DMF at 120 °C to give [n.3.0] bicyclic systems (n = 3–5) in good yields. Except for a ...
The reaction of this biradical with DNA is, presumably, identical to that for the biradicals produced from all of the enediyne antibiotics. 6.3.3.4.2 Dynemicin A Another member of the enediyne class of antitumor antibiotics is dynemicin A (6.85), which combines the structural features of ...
Article Open access 03 June 2024 Engineered cytochrome P450 for direct arylalkene-to-ketone oxidation via highly reactive carbocation intermediates Article Open access 13 July 2023 An enzymatic Alder-ene reaction Article 30 September 2020 Introduction...
High Pressure Diels Alder Reactions of 1-Vinyl-2,2,6-trimethylcyclohexene Catalyzed by Chiral Lewis Acids; An Enantioselective Route to a Drimane Sesquiterpene Precursor.terpeneshigh pressure reactionsChemInform is a weeklying Service, delivering concise information at a glance that was extracted from ...
vasta extract was prepared, and added into 7.5 mM (200 µL) neocuprine, 10 mM (200 µL) CuCl2, and 1M (200 µL) ammonium acetate buffer (pH 7.5) reaction mixture. This mixture was incubated for 30 min then absorbance was recorded at 450 nm using a BioTek Synergy HT microplate...
DIELS‐ALDER REACTIONS OF 6,9‐DIPROPYL‐1,4‐DIOXASPIRO(4.5)DECA‐6,8‐DIENE‐2,10‐DIONE WITH SUBSTITUTED ALKENES. AN ENTRY TO BICYCLO(2.2.2)OCT‐5‐ENE... Synthesis of 6,9-Dipropyl-1,4-Dioxaspiro[4.5] Deca-6,8-Diene-2,10-Dione and its Diels-Alder Reactions with Substituted Acety...
Ectomycorrhizal Cortinarius species participate in enzymatic oxidation of humus in northern forest ecosystems. New Phytologist 203: 245–256. https://doi.org/10.1111/nph.12791 Article PubMed CAS Google Scholar Bois, G., Y. Piché, M.Y.P. Fung & D.P. Khasa. 2005. Mycorrhizal inoculum ...
Homodimericine was prepared by a tandem thermal Diels–Alder reaction and cyclopentanol-forming ene reaction.221 The successful thermal ene reactions of 267, 271 and 273 forming cyclopentanols indicate that this is a suitable technique for highly substituted enals in which the aldehyde and alkene ...