Alcohol-associated Liver Disease (ALD) is a collection of liver disorders caused by prolonged and excessive alcohol consumption, ranging from fatty liver alterations to fibrosis and cirrhosis. This condition accounts for 5.9 % of all annual fatalities, making it a significant contributor to the ...
Innate immunity contributes effectively to the development of Alcohol-Associated Liver Disease (ALD). Particularly, human studies and murine models of ALD have shown that Complement activation plays an important role during the initial and later stages of ALD. The Complement System may contribute to ...
Alcohol-associated liver disease (ALD) is the most common cause of advanced hepatic disease worldwide. Increasingalcohol useover the past decade has led to significant healthcare burden as rates of this preventable disease rise. The American College of Gastroenterology convened a team of experts wit...
more than 2 million people had alcohol-associated cirrhosis in the US. Alcohol-associated liver disease is the primary cause of liver-related mortality and the leading indication for liver transplant, representing 40% to 50% of all liver transplant in high-income countries...
Alcohol-associated liver disease (ALD) is a chronic liver injury caused by prolonged heavy drinking and its pathogenesis is extremely complex. According to current researches, ethanol metabolism and the generation of some of its related metabolites, including acetaldehyde and reactive oxygen species, ar...
From fatty liver disease to cirrhosis to alcoholic hepatitis—here’s what you need to know. When it comes to alcohol, drinking too much too often can take a serious toll on the body. Medical researchers have examined the effects of everything from alcohol-related brain damage to immune dysfu...
Mitochondrial dysfunction and alcohol-associated liver disease: a novel pathway and therapeutic targetGastroenterologyMolecular biologydoi:10.1038/s41392-020-0128-8Mohamed A. AbdallahAshwani K. SingalSignal Transduction and Targeted Therapy
19.Kezer CA, Simonetto DA, Shah VH. Sex Differences in Alcohol Consumption and Alcohol-Associated Liver Disease.Mayo Clin Proc. 2021;96:1006-1016.[RCA][PubMed][DOI][Full Text][Cited by in Crossref: 20][Cited by inRCA: 54][Article Influence: 13.5][Reference Citation Analysis (0)] ...
liver transplant should be considered if the Model for End-Stage Liver Disease score remains greater than 17 after 3 months of alcohol abstinence. Between 2014 and 2019, the proportion of patients waiting for liver transplantation who had alcohol-associated liver disease increased from 22% to...
Alcohol-associated liver disease (ALD) is a liver injury associated with risk of development of cirrhosis in about 10–20% of cases. ALD is the primary cause of liver related mortality in the Western countries and the leading indication for liver transplantation (LT) accounting for 40–50% of...