Alcohol-associated liver disease (ALD) is the most common cause of advanced hepatic disease worldwide. Increasing alcohol use over the past decade has led to significant healthcare burden as rates of this preventable disease rise. The American College of Gastroenterology convened a team of ...
Alcohol-associated liver disease (ALD) is a liver injury associated with risk of development of cirrhosis in about 10–20% of cases. ALD is the primary cause of liver related mortality in the Western countries and the leading indication for liver transplantation (LT) accounting for 40–50% of...
This chapter focuses on the immune-mediated aspects of the pathogenesis of alcohol-associated liver disease (ALD). Alcohol not only directly injuries the liver but also exerts profound effects on other organs, which indirectly contribute to liver damage. Here, we will discuss the cellular effects ...
MetALD is a recently coined term that refers to a systemic entity to describe patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and simultaneous moderate alcohol consumption. The deleterious association of alcohol and metabolic risk factors synergistically increases the developmen...
From fatty liver disease to cirrhosis to alcoholic hepatitis—here’s what you need to know. When it comes to alcohol, drinking too much too often can take a serious toll on the body. Medical researchers have examined the effects of everything from alcohol-related brain damage to immune dysfu...
49,50 Interestingly, although autophagy can trigger ferroptosis, which can exacerbate alcohol-associated liver disease (ALD) pathology, autophagy appears to also impart a protective effect and decrease or blunt ALD pathology. These apparently opposing concepts have been indicated by question marks in ...
Alcohol-related liver disease (ARLD) has become the leading indication for liver transplantation in the United States, and patients with alcohol-associated... RM Weinrieb,MA Strong 被引量: 0发表: 2022年 S1085Effect of the COVID-19 Pandemic on Hospitalization for Alcohol-Associated Hepatitis Int...
Alcohol-associated liver disease is a well-validated indication for liver transplantation and recent data have refined the patterns of alcohol consumption and their impact on the pre- and post-LT periods. The selection process is a multidisciplinary approach that integrates liver and addiction parameters...
An expert panel has proposed 28 recommendations for the design and conduct of clinical trials for alcohol use disorders and alcohol-associated liver disease. This field has a scarcity of clinical trials, despite alcohol abuse and alcohol-related liver di
One challenge in studying ABD is that studies are primarily descriptive. In addition, investigations of the intestinal barrier in humans often consider only advanced stages of alcohol-associated liver disease (ALD), in which additional factors such asportal hypertensionor decompensation of liver function...