In addition, patients with underlying ARLD and heavy alcohol intake may develop alcoholic hepatitis, which is associated with high mortality. To date, the only effective treatment to treat ARLD is prolonged wit
Alcohol-related liver disease(ALD) encompasses a variety of clinical disorders:steatosis, alcohol-relatedacute liver failure(AR-ALF, formerly known as alcoholic hepatitis), and alcohol-associatedcirrhosis(AC). In the United States, ALD competes with chronic HCV as the leading indication forliver trans...
Alcohol-associated liver disease (ALD) is the most common cause of advanced hepatic disease worldwide. Increasingalcohol useover the past decade has led to significant healthcare burden as rates of this preventable disease rise. The American College of Gastroenterology convened a team of experts wit...
Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease Article Open access 27 March 2023 Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation Article Open access...
Alcohol intake can lead to changes in gut microbiota composition, even before liver disease development. These alterations worsen with advancing disease and could be complicit in disease progression. Microbial function, especially related to bile acid metabolism, can modulate alcohol-associated injury even...
Introduction Untreated hepatitis C virus (HCV) infection is associated with substantial morbidity and mortality due to cirrhosis, liver cancer, and related complications, especially for individuals with concomitant alcohol-associated liver disease.1 Treatment for HCV infection has changed rapidly since 2014...
Based on our analysis of significant biological pathways that are associated with the identified differentially expressed genes, real-time PCR was used to verify the status of differential expression and to exclude false positives. For internal control, we initially evaluated two genes (β-actin and ...
Similarly, beer/cider drinking was associated with approximately 18%, 16%, 36% and 11% higher risk of mortality, MACE, liver cirrhosis and accidents/self-harm respectively. Previous research has suggested higher risk of all-cause mortality among beer and spirit drinking when compared to wine ...
Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and...
“Research has shown that high doses of alcohol (around 14 drinks per week or more than five to six drinks at a time)does directly suppress the immune system, and that alcohol abuse is associated with increased risk of infectious diseases,” Mroszczyk-McDonald said. ...