Wang, G. Zhang et al., "AKT/GSK-3𝛽 regulates stability and transcription of snail which is crucial for bFGF- induced epithelial-mesenchymal transition of prostate cancer cells," Biochimica et Biophysica Acta: General Subjects, vol. 1840, no. 10, pp. 3096-3105, 2014....
41 NO.3 2023 ·实验研究· 施万细胞条件敲除 SEMA3B 通过 AKT/GSK3β 信号通路 抑制神经损伤后的华勒变性 徐元涛 1,2, 许逸舟 1,2, 许淑怡 2, 马心蕊 2, 王祥海 2, 朱立新 1*, 郭家松 *1,2 1. 南方医科大学珠江医院脊柱外科,广州 510510; 2. 南方医科大学基础医学院组织胚胎学教研室,广州 ...
目的:研究鳖甲煎丸对肝癌细胞Hep3B增殖和转移的影响,探讨其抗肝细胞癌的作用机制.方法:分别使用不同浓度的鳖甲煎丸药物血清培养Hep3B肝癌细胞,采用CCK8,细胞划痕实验观察肝癌细胞增殖和转移能力的改变;采用WesternBlot检测PI3K,p-AKT,GSK-3β,p-GSK-3β,E-cadherin,N-cadherin,Snail蛋白表达的变化;采用qPCR检测MMP...
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GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways. 仅用于科研。不用于诊断过程。未经明确...
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The Akt/GSK-3[beta] pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. Biochem. Biophys. Res. Commun. 409, 808-813.Sun B, Chen L, Wei X, Xiang Y, Liu X, Zhang X: The Akt/GSK-3[beta] pathway mediates flurbiprofen-induced ...
共转染1.0g Tau-V5和Pyk2 KD SHSY-5Y细胞组的P110β,P85α,p-AKT(Thr308),AKT,和GSK3β蛋白表达没有明显变化.p-P85α,P110α,p-AKT(Ser437)和p-GSK3β(Ser9)蛋白表达明显减少.结论Pyk2在雄性APP/PS1双转基因AD小鼠模型中高表达,且Pyk2通过PI3K/AKT/Gsk3b信号调控Tau蛋白PHF-1[Phospho-Tau(Ser396/...
GSK-3beta inhibition: at the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma. Cell Cycle 2008; 7: 2813-6.dal Col J, Dolcetti R. GSK-3beta inhibition: at the crossroad between Akt and mTOR constitutive activation to ...
Down-regulation of the AKT/GSK3b/b-catenin signalling pathway by the triterpene ursolic acid induced intrinsic apoptosis in human soft tissue sarcomasDown-regulation of the AKT/GSK3b/b-catenin signalling pathway by the triterpene ursolic acid induced intrinsic apoptosis in human soft tissue sarcomasAle...