Erianthridin suppresses non-small-cell lung cancer cell metastasis through inhibition of Akt/mTOR/p70S6K signaling pathwayNON-small-cell lung carcinomaMETASTASISCANCER-related mortalityCELL migrationEXTRACELLULAR matrixCancer metastasis is a major cause of the high mortality rate in lung cancer patients. ...
Activation of mTOR results in the phosphorylation of ribosomal protein S6 kinase, p70S6K. Akt also phosphorylates the two tumor suppressor genes, TSC1 and TSC2, which are negative regulators of the mTOR-S6K pathway. Phosphorylation of TSC1 and TSC2 results in ...
in patients with advanced or metastatic cancer. Invest New Drugs. 2015 Jun;33(3):710-9; Safety, tolerability and antitumour activity of LY2780301 (p70S6K/AKT inhibitor) in combination with gemcitabine in molecularly selected patients with advanced or metastatic cancer: a phase IB dose...
简述了 PI3K/Akt/mTOR/p70 S6K 信号通路作用于肝星状细胞(HSC)而对肝纤维化发生发展产生的作用,分析表明阻断该信号通路中任一靶点均能抑制 HSC 活化、增殖,促进 HSC 凋亡,抑制 HSC 分泌细胞外基质和延缓肝纤维化进程,阻断该通路有望成为肝纤维化的治疗策略。关键词:肝硬化;1 - 磷脂酰肌醇 3 - 激酶;蛋白...
AKT,也称为磷酸激酶B (PKB),在涉及细胞生长和分裂、细胞凋亡抑制和血管生成的多种级联信号传导机制中发挥着关键作用。同时,AKT也显示出重要的代谢作用,其中包括肌肉和脂肪细胞中的葡萄糖摄取或抑制神经元细胞死亡等。不过,对于处于PI3K/AKT/mTOR关键信号通路中心节点的
by Akt / mTOR / p70S6K Pathway Abstract Objective Autophagy, which is an evolutionarily conserved process, plays an important role in cells growth, development and homeostasis . Oxidative stress is a well-known stimulus of autophagy that facilitates the removal of damaged material. In this study, ...
To ascertain whether the Akt/mTOR pathway has an important role in Pae-induced autophagy, we investigated key proteins related to the Akt/mTOR pathway in Pae-treated ovarian cancer cells by western blot analysis. First, the phosphorylated levels of Akt, mTOR, and p70S6K were analysed. As ...
25、mal protein S6 kinase, p70S6K. Akt also phosphorylates the two tumor suppressor genes TSC1 and TSC2, which are negative regulators of the mTOR-S6K pathway. Phosphorylation of TSC1 and TSC2 results in suppression of their inhibitory activity and may also target the proteins for degradation....
5 reagents referenced in The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer.
We next examined whether the PI3K/AKT/mTOR/p70S6K pathway was involved in this process by analyzing the levels of phosphorylated p70S6K and AKT (Figure 4(b)). We found that Aβ25-35 remarkably decreased the levels of phosphorylated p70S6K and AKT compared to the nontreated group. Figure 4...