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(2008) Akt as a therapeutic target in cancer . Expert Opin Ther Targets 12 : 1139–1165doi: 10.1517/14728222.12.9.1139Steelman LS, Stadelman KM, Chappell WH, Horn S, Basecke J, Cervello M, Nicoletti F, Libra M, Stivala F, Martelli AM, McCubrey JA (2008) Akt as a therapeutic target...
AKT as a Therapeutic Target for Cancer 来自 NCBI 喜欢 0 阅读量: 125 作者:M Song,AM Bode,Z Dong,MH Lee 摘要: Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine thymoma viral oncogene homolog (AKT) plays a major role in the PI3K/AKT signaling ...
In summary, abnormality of the PI3K/AKT/NF-κB signaling pathway is a common occurrence in cancer, and it is involved in the development of MDR. It is also used as a target for reversing resistance. PI3K/AKT/mTOR The PI3K/AKT/mTOR signaling pathway plays a vital role in a variety of ...
AKT as a therapeutic target for cancer. Cancer Res. 79, 1019–1031 (2019). CAS PubMed Google Scholar Patel, S. Exploring novel therapeutic targets in GIST: focus on the PI3K/Akt/mTOR pathway. Curr. Oncol. Rep. 15, 386–395 (2013). CAS PubMed Google Scholar Mery, B. et al. ...
AKT as a therapeutic target for cancer. Cancer Res. 2019;79(6):1019–31. Article CAS PubMed Google Scholar Zhao L, Zhu L, Oh YT, Qian G, Chen Z, Sun SY. Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli...
摘要: •PI3K/AKT/mTOR pathway is frequently mutated or activated in ovarian cancer.•PI3K/AKT/mTOR pathway plays a crucial role in the progression of ovarian cancer.•P3K/AKTmTOR inhibition might be an effetive treatment for ovarian cancer.关键词:...
mutations in Akt1 and Akt3 also contribute to the hyperactivation of Akt in some types of tumors [63,64,65,66,67]. Akt activation promotes tumor progression and resistance to many chemotherapeutic agents [68,69,70]. Therefore, Akt is considered as a rational target for cancer treatment. The...
mutations in Akt1 and Akt3 also contribute to the hyperactivation of Akt in some types of tumors [63,64,65,66,67]. Akt activation promotes tumor progression and resistance to many chemotherapeutic agents [68,69,70]. Therefore, Akt is considered as a rational target for cancer treatment. The...
MINIREVIEW British Journal of Cancer (2017) 117, 159–163 | doi: 10.1038/bjc.2017.153 Keywords: Akt isoforms; cancer therapy; liver cancer; inflammation; diabetes Akt as a target for cancer therapy: more is not always better (lessons from studies in mice) Qi Wang1, Xinyu Chen1 and Nissim...