combinational therapyIntroduction: Targeted therapies in cancer aim to inhibit specific molecular targets responsible for enhanced tumor growth. AKT/PKB (protein kinase B) is a serine threonine kinase involved in several critical cellular pathways, including survival, proliferation, invasion, apoptosis, and...
trials for cancer therapy. Here, we highlight recent progress of Akt signaling pathway, review the up-to-date data from clinical studies of Akt inhibitors and discuss the potential biomarkers that may help personalized treatment of cancer with Akt inhibitors. In addition, we also discuss how Akt...
Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and metastasis to the resistance of tumors to treatment. Inflamma...
Apoptosis and molecular targeting therapy in cancer. Biomed. Res. Int. 2014, 150845 (2014). PubMed PubMed Central Google Scholar Levy, D. S., Kahana, J. A. & Kumar, R. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood ...
The present and future of PI3K inhibitors for cancer therapy Article17 June 2021 Introduction The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is a major signaling pathway in various types of cancer.1It controls hallmarks of cancer, including cell survival, metastasis and metabolism. The ...
M. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. J. Cell Physiol. 218, 13–21 (2009). CAS PubMed PubMed Central Google Scholar Liu, G. et al. An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate ...
Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention. Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced ri... Xin,Tong,C Jill,... - Anti-cancer agents in medicinal chemistry 被...
have been approved by FDA for cancer therapy. Indirect STAT3 inhibitors in currently on-going clinical trials are summarized in Table2[120,121,122,123,124]. Of note, indirect STAT3 inhibitors lack specificity for STAT3 and may cause fairly extensive kinase inhibition because the targeted molecules...
targetingcancerstemcellpathwaysfortherapy462020signaltransducttargetther REVIEWARTICLEOPENTargetingcancerstemcellpathwaysforcancertherapyLiqunYang1,2,PengfeiShi1,2,GaichaoZhao1,2,JieXu1,2,WenPeng1,2,JiayiZhang1,2,GuanghuiZhang1,2,XiaowenWang1,2,ZhenDong1,2,FeiChen3andHongjuanCui1,2Sincecancerstemcells(...
A series of molecules have been demonstrated to be able to inhibit AURKA activity. Although the majority also exerts effects on other members of the Aurora kinase family or even on other kinases, there is enough evidence to make some of them potent targets for cancer therapy both in vitro and...