Sushma MedikayalaCleveland Clinic Florida, Weston, FLKristi A. NjaravelilNova Southeastern University, Fort Lauderdale, FLSurafel K. GebreselassieCleveland Clinic Florida, Weston, FLAmerican Society of NephrologyJournal of the American Society of Nephrology...
The predictive ability of AKI (by any definition) with respect to crude 30-day mortal- ity was insufficient in patients with positive SOFA criteria for all five AKI definitions (AUROC curves between 0.55 and 0.57, data not shown). Other secondary outcome measures in SOFA patients such as ...
We need, however, keep in mind, that in the randomized clinical trials mentioned above, AKI was not well defined and was documented as an adverse event rather than a primary or secondary outcome. According to our findings, renal KIM-1 and urinary exosomal miR-26a may serve as better biomark...
An equivalent quantity of protein was mixed with an SDS-PAGE loading buffer (Beyotime) and was subjected to SDS-PAGE. The separated proteins were transferred onto PVDF membranes and probed with primary antibody and an appropriate peroxidase-conjugated secondary antibody. Bands were visualized using a...
Megan N. NickersonOregon Health & Science University, Portland, OR;Tahnee GroatOregon Health & Science University, Portland, OR;Michael HutchensOregon Health & Science University, Portland, OR;American Society of NephrologyJournal of the American Society of Nephrology...
Cardiorenal syndrome type 3 (CRS 3) occurs when an acute kidney injury (AKI) leads to the development of cardiac dysfunction. It is associated with significant morbidity and mortality and is becoming increasingly prevalent. Mitochondrial dysfunction in renal tubular cells has been proposed as a ...
Mechanisms of Difference in AKI-CKD Transition due to Acute Cardiorenal Syndrome and Ischemia-Reperfusion Injurydoi:10.1681/ASN.20223311S173bYoshio FunahashiOregon Health & Science University, Portland, ORJessica F. HebertOregon Health & Science University, Portland, ORAdam C. Munhall...