Both hypovolemia (pre-renal AKI from over diuresis) and hypervolemia (vascular congestion from under diuresis) can result in a hemodynamic AKI secondary to hypoperfusion. Since there is no test to differentiate the mechanism of hypoperfusion, what should be done with diuretic therapy? Moreover, ...
ADQI consensus on AKI biomarkers and cardiorenal syndromes. Contrib Nephrol. 2013b;182:99–116. Article PubMed Google Scholar De Backer D, Donadello K, Taccone FS. Microcirculatory alterations: potential mechanisms and implications for therapy. Ann Intensive Care. 2011;1:27. Article PubMed Pub...
1).26,27 Prerenal AKI is defined by renal hypoperfusion with a subsequent decrease in GFR and urine output without damage to the renal parenchyma. This is an adaptive response through the renin-angiotensin-aldosterone system (RAAS) to extrarenal insults.28 GFR is maintained through a wide ...
NHE3 Ischemia, pre-renal, post-renal AKI Cytokines (IL-6, IL-8, IL-18) Toxic, delayed graft function Actin-actin depolymerizing F Ischemia and delayed graft function α-GST Proximal T injury, acute rejection π-GST Distal tubule injury, acute rejection L-FABP Ischemia and nephrotoxins Netrin...
Joannidis M, Druml W, Forni LG, Groeneveld ABJ, Honore PM, Hoste E, et al. Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017: Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medici...
Cardiorenal syndrome (CRS) represents a subset of AKI or CKD that develops in the context of worsening cardiovascular disease, recognizing that not all renal dysfunction developing in patients with cardiovascular disease is due to CRS (Central Illustration) (3,4). Download: Download high-res image...
and renal outcomes (eGFR and CI-AKI).#After 1:1 propensity score matching (PSM) (176 dapagliflozin vs. 176 control), the dapagliflozin group showed significantly lower PMI/4aMI rates pre-PSM (39.78% vs. 66.99%; OR 0.862, 95% CI 0.823–0.904;p<0.001) and post-PSM (39.77% vs. 60.23...
Moreover, a retrospective, single-center observational study has identified the CALLY index as an autonomous risk predictor for the onset of acute kidney injury (AKI) [28]. In this research, we conducted a pioneering exploration of the CALLY index's utility in forecasting outcomes for individuals...
Overall 16 patients (4%) experienced early AKI. These patients were more likely to suffer from pre-existing chronic cardiac disease or diabetes mellitus. At presentation, BNP (334pg/ml [130-1119] vs. 113pg/ml [52-328], p<0.01) and NGAL (269ng/ml [119-398] vs. 96ng/ml [60-199]...
First, because SGLT2 inhibitors are natriuretic, these agents can induce afferent glomerular arteriolar constriction, thereby decreasing renal blood flow. Theoretically, these changes may contribute to an increased risk of acute kidney injury (AKI), although this has not been evident in clinical trials...