Here we found that AIM2 regulates the innate immune sensors pyrin and ZBP1 to drive inflammatory signalling and a form of inflammatory cell death known as PANoptosis, and provide host protection during infections with herpes simplex virus 1 and Francisella novicida. We also observed that AIM2, ...
与野生型BMDM相比,在HSV1或F.novicida感染后,Mefv-/-和Zbp1-/-BMDMs中的炎性分子caspase-1、GSDMD和GSDME、凋亡分子caspase-8、-3和-7以及坏死性分子RIPK3和MLKL的激活减少,而在AIM2-/-和Mefv-/- Zbp1-/-BMDMs中则完全失去激活。综上所述,这些数据表...
然而,与 WT BMDMs 相比,作者观察到 IAV 或 HSV1 感染后,Zbp1 -/- 或 Aim2 -/- BMDMs 中的热凋亡分子 caspase-1 和 GSDMD 以及凋亡分子 caspase-8、caspase-3 和 caspase-7 的激活完全丧失,而且坏死分子 MLKL 缺乏磷酸化。作者还观察到在 IAV 感染期间内源性 ASC 与 NLRP3、ZBP1、caspase-8 和 RIP...
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature. 2021;597:415–9. Article CAS PubMed PubMed Central Google Scholar Liu Z, Wang M, Wang X, Bu Q, Wang Q, Su W, et al. XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to ...