2 Lin, L., Dai, Y. & Xia, Y. An overview of aryl hydrocarbon receptor ligands in the Last two decades (2002-2022): A medicinal chemistry perspective.Eur J Med Chem244, 114845 (2022). https://doi.org:10.1016/...
这提供了饮食与肠道内皮细胞状态之间的另一种联系,而肠道内皮细胞是肠道健康的重要因素。相关研究结果于2023年8月16日在线发表在Nature期刊上,论文标题为“Endothelial sensing of AHR ligands regulates intestinal homeostasis”。 参考资料: 1. Jack Major et al. Endothelial AHR activity prevents lung barrier disr...
1.Rothhammer, V. & Quintana, F. J. The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease. Nat. Rev. Immnunol.19:184-197. 2019. 2.Murray, I. A., Patterson, A. D. &Perdew, G. H. AH recep...
总的来说，这项研究揭示了AHR在肺部屏障保护功能中的关键作用，发现肠-肺轴可以通过AHR影响病毒感染导致的肺损伤，为未来治疗流感和其他呼吸道病毒感染提供了新的思路和方向。Nature杂志在同一期杂志上发表另一篇类似工作，题为Endothelial sensing of AHR ligands regulates intestinal homeostasis 的文章（详见今日BioArt报...
AhR ligands include polycyclic aromatic hydrocarbons, including the carcinogen benzo(a)pyrene and other components of cigarette smoke (3,4). Naturally occurring AhR ligands include flavonoids, which are aromatic plant secondary compounds commonly found in vegetables and fruits (3). Cytoplasmic aryl ...
2.Murray, I. A., Patterson, A. D. &Perdew, G. H. AH receptor ligands in cancer: friend and foe. Nat. Rev. Cancer. 14:801-814. 2014. 3.Gutcher, I. et al. 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer. WO2018146010A1. (2018) ...
为了深入探讨这一问题,研究人员在《Nature Communications》期刊上发表了题为“Restoring the balance of host- and microbiota-derived AHR ligands improves post-stroke outcomes”的研究论文。该研究揭示了中风后肠道微生物群失调与AHR配体来源失衡之间的关联,并提出了通过恢复宿主和微生物群来源的AHR配体平衡来改善中风...
2.Murray, I. A., Patterson, A. D. &Perdew, G. H. AH receptor ligands in cancer: friend and foe. Nat. Rev. Cancer. 14:801-814. 2014. 3.Gutcher, I. et al. 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer. WO2018146010A1. (2018) ...
Furthermore, endothelial sensing of dietary AHR ligands was required for optimal protection against enteric infection. In human endothelial cells, AHR signalling promoted quiescence and restrained activation by inflammatory mediators. Together, our data provide a comprehensive dissection of the effect of ...
Endothelial sensing of AHR ligands regulates intestinal homeostasis 2023-08-16, doi: 10.1038/s41586-023-06508-4 Nature:饮食中的AHR配体,或可减轻肺部感染损伤 Nature——[64.8] ① 环境感受器芳香烃受体(AHR)在肺部血管内皮细胞中高度活跃;② 内皮AHR对流感诱发的小鼠肺血管渗漏起保护作用,其缺失会加剧流感引...