1.7Impact Factor Articles & Issues About Publish Submit your articleGuide for authors About the journalAging Brain is an Open Access journal that complements Neurobiology of Aging which, in its 40th anniversary in 2020, is the premier journal in the field of aging...
However, age is the main risk factor for neurodegenerative disorders such as Alzheimer's disease (AD) that impact on cognition. Oscillatory electromagnetic brain activity is a hallmark of neuronal network function in various brain regions. Modern neurophysiological techniques including electroencephalography...
Jorge BusciglioUniversity of California, IrvineIrvine, United States Specialty Chief EditorCellular and Molecular Mechanisms of Brain-aging Agustin IbanezLatin American Brain Health Institute (BrainLat)Santiago, Chile Specialty Chief EditorAlzheimer's Disease and Related Dementias Yu-Min KuoDepartment of Cel...
This finding highlights the importance of VBI in mild cognitive impairment and suggests that the impact of cerebrovascular disease should be considered with respect to defining the etiology of mild cognitive impairment.Deposition of β-amyloid (Aβ) and vascular brain injury (VBI) are the 2 most ...
Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology 2011; 77: 461–468. 52 Franke K, Gaser C, Manor B, Novak V. Advanced BrainAGE in older adults with type 2 diabetes mellitus. Front Aging Neurosci 2012; 5: 90. 53 Espeland MA, Bryan ...
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset...
amyloid-β aggregations [27] through the brain. Though AD progression can be variable, some regions show amyloid or tau pathology earlier than others [44]. It is unknown whether regional differences in epigenetic age might help explain the differential impact of AD pathology amongst brain regions....
6. Shahidehpour, R.K. et al. Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain. Neurobiol Aging 99, 19-27 (2021).7. Perry, V.H. & Holmes, C. Microglial priming in neurodegenerative disease. Nat Rev Neurol 10, 217-24 (2014).8....
The brain is the most complex organ system in the human, both in the intricacy of its cellular architecture and in the extent of its repertoire of macromolecules. presents the current state of understanding of molecular, cellular, and functional changes that occur in normal brain aging, and ...
The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many substances, resulting in nourishment of the CNS, its homeostatic regulation and communi...