(University of Massachusetts Medical School). T2 cells are TAP-deficient T cells expressing HLA-A2 protein on the cell surface52. T2 cells were seeded into 96-well plates and then incubated with peptides at a final concentration of 20 µM at 37 °C for 4 hours. DMSO was set ...
their signatures with the reverse disease signature in the latent embedding obtained by an overparameterized autoencoder and sharing data across cell types to obtain missing drug signatures via synthetic interventions. Blue and orange points in the latent space represent data associated with the drug sc...
The couple moved to the Boston area shortly after getting married, settling first in Watertown, then in Lexington, Massachusetts, where she lived for the remainder of her life. After raising her three children through their formative years, Davette earned her graduate degree in Education and began...
37]. However, laboratory animal models exhibit low genetic diversity, a gut microbiota composition strongly influenced by captivity [8,10,38,39], and cannot reflect the more gradual influence of host age on gut microbial composition expected for long-lived...
2012 - 2013 season vaccine strains included A/California/7/2009, A/Victoria/361/2011, and B/Wisconsin/1/2010. The 2014 - 2015 season vaccine was identical to that of the 2013-2014 season and included A/California/7/2009, A/Texas/50/2012, B/Brisbane/60/2008, and B/Massachusetts/2/...
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA Stephanie A Schultz & Jasmeer P Chhatwal Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA Carlos Cruchaga, Laura Ibanez & Celeste Karch NeuroGenomics & Informatics Center, Washington University ...
The original cohort was a two-thirds population sample of Framingham, Massachusetts, and aimed to identify risk factors for cardiovascular disease. Additional cohorts have since been recruited, consisting of the children and grandchildren of the original cohort and their spouses. DNAm data were ...
Data on androgen deficiency (defined using both signs/symptoms plus total and calculated free testosterone) were available for n = 1691 (baseline) and n = 1087 (follow-up) men from the Massachusetts Male Aging Study. Crude and age-specific prevalence and incidence rates were calculated. Based ...
The US Department of Veterans Affairs (VA) NAS is supported by the National Institute of Environmental Health Sciences (NIEHS; R01ES015172 and R01ES021733) as well as by the Cooperative Studies Program/ERIC, US Department of Veterans Affairs, and is a research component of the Massachusetts ...
ArticleOpen access27 January 2020 Introduction The brain shows major changes over the course of aging. It is not fully understood how neurodegenerative diseases affect brain regions and networks that are also affected by normal aging. However, increasing evidence suggests that neural systems vulnerable ...