For the study, Clark and his colleagues looked at biopsies and other tests of more than 270 men with various stages of prostate cancer, as well as samples of prostates that have been removed, comparing urine tests with the patients' diagnosis. Dr. Anthony D'Amico, a professor of radiation ...
Prostate cancer is the second leading cause of cancer deaths among men in the United States, and it disproportionally affects Black men, who are twice as likely to be diagnosed with and die of the disease. Catching this cancer in its early stages is key, as the five-year surviva...
The role of dysregulation of mRNA alternative splicing (AS) in the development and progression of solid tumors remains to be defined. Here we describe the first comprehensive AS landscape in the spectrum of human prostate cancer (PCa) evolution. We find that the severity of splicing dysregulation ...
Highly aggressive cancers include PDAC, NSCLC, CRC, hepatocellular carcinoma (HCC) or liver cancer, breast cancer, prostate cancer, and brain tumors, such as glioblastoma. Neuroblastoma is an example of a highly aggressive solid tumor in early childhood. Below we consider their oncogenic expression ...
Early diagnosis is pivotal to the treatment of all cancers, but some reveal their machinations far earlier than others. Prostate cancer is unfortunately one that might not show itself until in its later, more aggressive stages, so the search is on for tools that can pick it up earlier in th...
However, compared to other SIRTs, the role of SIRT5 in cancer has not been extensively studied. Here, we revealed significantly decreased SIRT5 levels in aggressive PCa cells relative to the PCa stages. The correlation between the decrease in the SIRT5 level and the patient’s reduced survival...
To address this issue, we systematically prioritized and evaluated individual effects and complex interactions among 172 apoptotic SNPs in relation to PCA risk and aggressive disease (i.e., Gleason score ≥ 7 and tumor stages III/IV). Single and joint modifying effects on PCA outcomes among Europ...
We investigated the transcriptional programme associated with pimonidazole staining in prostate cancer. Methods: Index tumour biopsies were taken by image guidance from an investigation cohort of 52 patients, where 43 patients received pimonidazole before prostatectomy. Biopsy location within the index tumour...
Liu_prostate cancer np Irshad_indolent PCa signature NES=2.20 P=0.000 FDR=0.000 0.5 0.0 –0.1 NES=1.43 P=0.063 FDR=0.109 0.6 0.3 0.0 ADT treatment Rajan_before ADT NES=3.09 P=0.000 FDR=0.000 k DU145 l mr Beltran_NEPC signature Tzelepi_SCPC/LCNEC_Up Varambally_CRPC_Up q Rajan_after...
Can a prostate infection cause cancer? Can prostate cancer cause testicular cancer? How many stages of prostate cancer are there? Can colon cancer spread to the prostate? How aggressive is testicular cancer? What genetic mutation causes prostate cancer?