Reasons for this superior antimicrobial activity could be due to the secondary structure that this peptide folds into upon contact with bacterial membranes and the high content of hydrophobic residues (46%) of this peptide, compared to the other H5-derived peptides. In fact, it has been shown ...
In summary, the data presented herein clearly establish that a fusion protein CD4(178)-PE40 specifically and efficiently kills HIV-infected cells. This allows the use of this recombinant toxin as a therapeutic agent for the control and treatment of AIDS. A therapeutic composition in accordance wit...
such as that which occurs in the absence of effective antibiotic treatment of the bacterial infection, the host immune system attacks normal tissues, and heart valvular defects ensue from tissue scarring mediated by the immune response. Furthermore, the patient develops arthritis, due to the respons...
An anti-infectious agent as used herein is an agent which reduces the activity of or kills a microorganism and includes: Aztreonam; Chlorhexidine Gluconate; Imidurea; Lycetamine; Nibroxane; Pirazmonam Sodium; Propionic Acid; Pyrithione Sodium; Sanguinarium Chloride; Tigemonam Dicholine; Acedapsone...
There was a 23% increase in viable cells in the presence of the inhibitor (FIG. 19), providing a strong indication that SC104 kills colorectal cells by a ‘classic’ apoptotic pathway. Experiment 5 Methods Inhibition of cell growth. 1×103 colorectal C170, C168, C146, CaCO2, Colo205, Lo...
The additive to the water-dispersible topcoat can also include an anchor group coupled to the HBP core. The anchor group provides a means to permanently fix the additive in the matrix upon curing or drying. However, it is appreciated that the kinetics of this reaction must be controlled to ...
showed that endolysin PVP-SE1gp36 remains thermo-resistant up to 90 °C [61]. In contrast, the phage endolysin Lys68 activity was completely lost upon exposure to 100 °C for 30 min but the enzyme remains active after 30 min incubation at 40 °C and 60 °C; however, it did ...
albicans growth in the coculture setup, and this also suggested that the polymicrobial interaction might be much more complex in the gut and other organs of the hosts, where several bacterial species reside and may have different impacts on fungal growth. Furthermore, to ascertain the differential...
BV (but also melittin and PLA2) has the ability to inhibit the multiplication of bacteria belonging to different genera due to affecting the bacterial cell membranes. The formation of pores leads to the loss of the integrity of membranes leading to cell lysis [5]. It has been shown that ...