This study aims to clarify the neuropathologic correlates of longitudinal brain atrophy.ObjectiveTo examine the association between brain atrophy during life and neuropathology in an elderly population.DesignAutopsy study of a cohort of elderly individuals.SettingCommunity-based population.ParticipantsSeventy-...
The aging brain undergoes major changes in its topology. The mechanisms by which the brain mitigates age-associated changes in topology to maintain robust control of brain networks are unknown. Here we use diffusion MRI data from cognitively intact parti
To assist our understanding of the brain-cognition associations, we conducted two sets of multiple regression analyses. First, in additional to visual inspection of the CIs in PLSC, two multiple regressions were conducted. In each regression, L2AoA or ToM was the dependent variable, while age gro...
Preclinical studies have shown encouraging results, showing that Japanese W + NMN25000 is able to improve cognitive function, reduce neuronal loss in experimental animals, and may reverse some signs of brain atrophy induced by age.日本W+NMN25000作为细胞能量代谢和DNA修复的关键辅酶,在维持神经元健康与...
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Beal MF, Matthews RT, Tieleman A, Shults CW (1998) Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res 783 (1):109–114 Google Scholar Beal MF, Oakes D, Shoulson I, Henchcliffe...
Third, brain atrophy with age created a phenomenon known as cavitation by pulling on the tissue around the blood vessels, which may explain the existence of the dilation of PVSs. The fourth proposed mechanism is damage to the Brain Blood Barriers (BBB). High blood pressure, age, or ...
Brain aging poses a significant risk factor for dementia, with aging-induced low-grade brain inflammation playing a role in the onset of dementia. In an aging model, utilizing the senescence accelerated mouse-8 (SAMP8), Xu et al. demonstrated that spermidine and spermine exhibit potential in am...
brain can stimulate astrocytes, neuroinflammation and reduce cognitive function, especially in the subdomain of memory [164]. High circulating concentrations of TMAO also downregulated the antioxidant enzyme methionine sulfoxide reductase A in the hippocampus of aged rats with induced cognitive impairment ...
cancer to brain metastasis72and chemotherapy-induced cognitive impairments, commonly known as “chemo brain”. In addition, it’s important to exercise caution when considering the potential causal link between breast cancer and GM-BAG, as MR analyses are susceptible to population selection bias73due...