Ageing is a major risk factor that contributes to increased mortality and morbidity rates during influenza A virus (IAV) infections. Macrophages are crucial players in the defense against viral infections and display impaired function during ageing. However, the impact of ageing on macrophage function...
G. et al. Senescent cells: an emerging target for diseases of ageing. Nat. Rev. Drug Discov. 16, 718–735 (2017). Article CAS PubMed PubMed Central Google Scholar Childs, B. G. et al. Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science 354, 472–...
and A.U.; Ministero della Salute Italiana (Progetto Giovani Ricercatori 58/GR-2011−02348160) to M.B.; European Union (EU) funding within the NextGenerationEU-MUR PNRR Extended Partnership initiative on Consequences and challenges of ageing, Ageing Well in an Ageing Society (Project no. PE...
As the second most common age related neurodegenerative disease after Alzheimer's disease, the health, social and economic impact resulting from Parkinson's disease will continue to increase alongside the longevity of the population. Ageing remains the biggest risk factor for developing idiopathic Parkins...
Ageing is a strong risk factor for the development of AMD. Blue iris is more likely to develop AMD than the brown iris.17 Systemic factors such as cardiovascular disease are also risk factors for AMD18; elevated blood pressure17,19 and atherosclerosis20 can increase the risk of AMD. The ...
Eeles, E. M., White, S. V., O'Mahony, S. M., Bayer, A. J. & Hubbard, R. E. The impact of frailty and delirium on mortality in older inpatients.Age Ageing41, 412–416 (2012). ArticlePubMedGoogle Scholar Panza, F.et al. Different models of frailty in predementia and dementia...
impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation | Age and Ageing | Oxford Academic The hallmarks of dry skin (xerosis) are scaliness and loss of elasticity. Decreased hydration and a disturbed lipid content of the stratum corneum are also...
Amino acids (AAs) are one of the primary metabolic substrates for cardiac work. The correlation between AAs and both atrial fibrillation (AF) and aging has been documented. However, the relationship between AAs and age-related AF remains unclear. Initial
The other factor is a dilution effect on late reproduction, should the population be growing in size. Therefore, the likelihood of detrimental mutations, with or without earlier pleiotropic benefits, to spread and persist in the population would increase the later their age of action. Ageing would...
Fibroageing: an ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology. Ageing Res. Rev. 70, 101393 (2021). Article CAS Google Scholar Stolz, M. et al. Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force ...