Isotype IgG Clonality Polyclonal Host Rabbit Gene AGAP1 Purity Antigen Affinity-purified Innovator's Reward Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's RewardApplications/DilutionsDilution...
We characterized one gene product, AGAP1. AGAP1 had PA- and PIP2-dependent Arf GAP activity. The GLD imparted the PA dependence. AGAP1 induced the formation of punctate structures that contained Rab4 and AP1 and were an intermediate in transferrin trafficking in cells. AGAP1 also has ...
UniProt ID: (Human) Q9UPQ3 Entrez Gene ID: (Human) 116987 功能 GTPase activator activity GTP binding phospholipid binding metal ion binding 参与通路 small GTPase mediated signal transduction protein transport positive regulation of GTPase activity 性能保障 只要您发现Invitrogen抗体在实验中的表现与...
on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal ...
Both genes have been described as being involved in endosomal trafficking, and AGAP1 in particular has been shown to be expressed in the developing brain and to play a role in dendritic spine formation and synapse function, making it a potential causative gene to our patient's phenotype....
The c.40_42delAGA variant in the phospholamban gene (PLN) has been associated with dilated and arrhythmogenic cardiomyopathy, with up to 70% of carriers experiencing a major cardiac event by age 70. However, there are carriers who remain asymptomatic at older ages. To understand the mechanisms...