Mechanistically, we revealed that AGAP2-AS1 was secreted outside cells by incorporation into exosomes in an hnRNPA2B1-dependent manner. More importantly, co-culture AGAP2-AS1-containing exosomes with sensitive cells reduced the trastuzumab-induced cell death, and silencing of AGAP2-AS1...
AGAP2-AS1在非小细胞肺癌组织中的表达及临床意义
分层分析显示,AGAP2-AS1表达与肿瘤直径,分化程度,TNM分期和淋巴结转移有关(P<0.05).62例AGAP2-AS1低表达者的中位总生存期(OS)为59.0个月,长于61例高表达者的34.0个月(HR=2.454,95%CI:1.528~3.943,P<0.001);Kaplan-Meier Plotter预后在线分析显示,574例AGAP2-AS1低表达者的中位OS为110.27个月,长于570例...
Furthermore, MSC culture-induced AGAP2-AS1 regulates stemness and trastuzumab resistance via activating FAO. Mechanistically, AGAP2-AS1 is associated with HuR, and the AGAP2-AS1–HuR complex could directly bind to the CPT1, increasing its expression via improving RNA stability. In addition, AGA...
研究背景与目的银屑病是由遗传,环境,免疫等多因素诱发的慢性炎症性皮肤病,多种因素共同作用于角质形成细胞,最终导致其过度增殖.长链非编码RNA(lncRNA)是一类真核生物中长度大于200nt的非编码RNA分子,在多种癌症中促进肿瘤生长.LncRNAAGAP2 antisense RNA1(AGAP2-AS1)是近些年新发现的 lncRNA,已经发现其在肺癌,肝癌...
RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4 Bingqing Hui, Hao Ji, Yetao Xu, Juan Wang, Zhonghua Ma, Chongguo Zhang, Keming Wang & Yan Zhou Cell Death & Disease volu...
Next, the ectopic expression, knockdown, and reporter assay experiments were all employed to elucidate the mechanism of AGAP2-AS1/miR-195-5p/FOSL1 in the processes of EC cell proliferation, cell cycle, apoptosis, invasion, and migration as well as tumor growth. Knockdown of AGAP2-AS1 or ...
Long non-coding RNA (lncRNA) AGAP2-AS1 is an identified oncogene in several types of cancers. However, the role of AGAP2-AS1 in LSCC remains unclear. The expression levels of AGAP2-AS1 in LSCC tissues and cell lines were measured using qRT-PCR. AGAP2-AS1 was knocked down in LSCC ...
AGAP2-AS1RNA结合蛋白IGF2BP2LRG1背景:膀胱癌(bladder cancer,BCa)是泌尿系统第二大常见恶性肿瘤,有着高病发率和死亡率.大多数膀胱癌是低级别的非肌层浸润性乳头状肿瘤,称为非肌层浸润性膀胱癌(non-muscle invasive bladder cancer,NMIBC),NMIBC包括Ta期,T1期肿瘤和原位癌(CIS).NMIBC的特点为是复发率高,并...
Here, we elucidated the function and possible molecular mechanisms of the effect of lncRNA-AGAP2-AS1 on the biological behaviors of HCC.doi:10.1186/s13046-019-1188-xZhikui LiuYufeng WangLiang WangBowen YaoLiankang SunRunkun LiuTianxiang Chen...