The popular name of African trypanosomiasis--sleeping sickness--underestimates the disease's severity. Tsetse flies transmit two subspecies of the pathogen Trypanosoma brucei. The rhodesiense variant, found...
Trypanosoma brucei is spread by tsetse flies to the mammalian bloodstream, thereby causing African Sleeping sickness and the livestock disease nagana1. A protective coat comprised of ~107 Variant Surface Glycoprotein (VSG) molecules is crucial for its survival as an extracellular pathogen2...
Sleeping sickness is one of the best-known insect-borne diseases in Africa, affecting more than 30 mammal taxa, including wild animals, domestic livestock and people. The causal agents are parasitic protozoa of the genusTrypanosomathat are principally spread by various species of tsetse fly (Glossin...
展开 关键词: African sleeping sickness apolipoprotein L-1 haptoglobin hemoglobin haptoglobin related protein high density lipoprotein innate immunity trypanosome lytic factor DOI: 10.4161/viru.3.1.18295 被引量: 26 年份: 2012 收藏 引用 批量引用 报错 分享 全部...
Elimination of sleeping sickness hindered by difficult diagnosis Bull. World Health Organ., 91 (10) (2013), p. 718 Google Scholar [10] O.C. Hutchinson, H. Webb, K. Picozzi, S. Welburn, M. Carrington Candidate protein selection for diagnostic markers of African trypanosomiasis Trends Parasitol...
African Trypanosomiasis is known as the human sleeping sickness caused by Trypanosoma brucei gambiense (95%) and Trypanosoma brucei rhodesiense. This vector-borne parasitic disease is endemic in sub-Saharan Africa, where the tsetse fly vector is found. It is transmitted to human via the faeces of...
protective structures such as the peritrophic matrix, the oxidative detoxification of toxic molecules, or the pathogen recognition process. The fact that both chronic and acute forms of sleeping sickness exist in Africa, caused respectively byT. b. gambienseandT. b. rhodesienseand transmitted ...
The sleeping sickness parasite Trypanosoma brucei has a variant surface glycoprotein (VSG) protective coat that undergoes extensive antigenic variation during evasion of host immunity (reviewed in Refs. 23, 24, and 30, 31, 32). When antibodies kill trypanosomes expressing a specific VSG, a ...
African sleeping sicknessapolipoprotein L-1haptoglobin hemoglobinhaptoglobin related proteinhigh density lipoproteininnate immunitytrypanosome lytic factorThe haptoglobin-hemoglobin receptor (HpHbR) of African trypanosomes plays a critical role in human innate immunity against these parasites. Localized to the ...
MULTIPLE OPPORTUNISTIC PATHOGEN PREVENTIVE THERAPYLeishmaniasis, Chagas' disease, and African trypanosomiasis (sleeping sickness) pose substantial therapeutic challenges. In most situations, stibogluconate sodium and meglumine antimoniate, both pentavalent antimonials, remain the treatment of choice...