Trypanosoma bruceiis a protozoan that causes African sleeping sickness in humans. Many glycoconjugate compounds are present on the entire cell surface ofTrypanosoma bruceito control the infectivity and survival
Step-by-Step Solution:1. Identify the Disease: The question asks about the pathogen that causes African sleeping sickness. This disease is known to be transmitted by a specific vector.2. Identify
The sleeping sickness focus of Campo lies along the Atlantic coast and extends along the Ntem River, which constitutes the Cameroonian and Equatorial Guinean border. It is a hypo-endemic focus with the disease prevalence varying from 0.3 to 0.86% during the last few decades. Investigations on ...
Trypanosoma brucei is spread by tsetse flies to the mammalian bloodstream, thereby causing African Sleeping sickness and the livestock disease nagana1. A protective coat comprised of ~107 Variant Surface Glycoprotein (VSG) molecules is crucial for its survival as an extracellular pathogen2...
Trypanosoma brucei is a protozoan parasite and the causative agent of human African trypanosomiasis, also known as sleeping sickness, and Nagana in livestock, with the human disease being typically fatal without therapy (1). T. brucei is transmitted by the tsetse fly and exists as an extracellular...
or becoming more common due to changes in contact.2 In Angola's Kasanje district a disastrous epidemic in 1690 of "swelling" inchac¸a˜o which the population of the capital fled into the forest to escape, has never been identified (Miller 1982); but sleeping sickness was sometimes refe...
first stage haemolymphatic phase showed symptoms of fever, headaches and joint aches. The progression to the second stage entails the parasitic invasion of the blood-brain-barrier, thus infecting the central nervous system and causing neurological disorder. Without treatment, sleeping sickness is fatal...
The sleeping sickness parasite Trypanosoma brucei has a variant surface glycoprotein (VSG) protective coat that undergoes extensive antigenic variation during evasion of host immunity (reviewed in Refs. 23, 24, and 30, 31, 32). When antibodies kill trypanosomes expressing a specific VSG, a ...
Metronidazole and suramin combination in the treatment of arsenical refractory Rhodesian sleeping sickness—A case study. Trans. R. Soc. Trop. Med. Hyg. 1996, 90, 422. [Google Scholar] [CrossRef] Pepin, J.; Milord, F.; Mpia, B.; Meurice, F.; Ethier, L.; DeGroof, D.; Bruneel, ...