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NOVEL TECHNOLOGY Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality. LEARN MORE NOVEL TECHNOLOGY NEW SOLUTION Canine CAR-T Therapy Development: From early target discovery, CAR design and const...
How the T cell receptor (TCR) can initiate developmental programs resulting in opposing thymocyte fates (survival versus death) is a central question in immunology. Much work supports the idea that the binding strength (affinity) between TCR and self-peptide major histocompatibility complex (pMHC) ...
Binding of peptide/MHC (pMHC) complexes by TCR initiates T cell activation. Despite long interest, the exact relationship between the biochemistry of TCR/pMHC interaction (particularly TCR affinity or ligand off-rate) and T cell responses remains unresolved, because the number of complexes examined ...
TCR engagement in T-cells also leads to Tyr-323 phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16. PPM1D also mediates dephosphorylation and inactivation of MAPK14. Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases ...
"First AID" for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation. Adoptive cell transfer (ACT) of tumor specific T lym-phocytes, after host immunodepletion, was shown to mediate objective cancer regression of metastatic mela-noma. Effective T cell activation depends, ...
Adoptive T cell therapy is a promising therapeutic approach with the potential to eradicate otherwise incurable cancers. Through T cell receptor (TCR) gene therapy, donor- or patient-derived T cells can be reprogrammed to recognize tumor-associated antigens (Ags); the ability of these engineered ...
TCR repertoires, we found that the immunodominance of high-affinity T cell clones declined during the chronic infection phase, likely due to cellular senescence. These data showed that under conditions of chronic antigen exposure, low-affinity TCRs preferentially expanded within the TCR repertoire, ...
TCR-CAT may be a very good alternative to the expensive TCR-T, which is considered an effective personalized cyto-immunotherapy. 展开 关键词: cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT DOI: 10.1007/s11684-018-0677-1 ...
The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat Immunol 2013; 14(11):1155-65.Man K, Miasari M, Shi W et al (2013) The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and ...