In vivo affinity maturation of B cells edited at their native loci may facilitate the development of broad, potent and bioavailable antibodies.#Mouse B cells can be reprogrammed via Cas12a to express human antibodies that when affinity-matured in recipient mice generate broader and more potent ...
The adaptive strategy works because receptors of adaptive immune cells can mount an immune response based on their affinity for antigens. Thus, affinity discrimination is central to adaptive immunity and has important biomedical ramifications. Due to its intricate connection to the affinity maturation ...
the post-vax timepoint was as early as 7 or 9 days after vaccination, the high SHM levels observed at this time likely reflected affinity maturation that had occurred in the time leading up to the vaccination, archived in memory B cells, rather than an increase in SHM following vaccination....
Antigen-activated B cells diversify variable regions of B cell antigen receptors by somatic hypermutation in germinal centers (GCs). The positive selection of GC B cells that acquire high-affinity mutations enables antibody affinity maturation. In spite of considerable progress, the genomic states under...
Administration of NP-CGG on day 77 caused little change in the proportion of the Gly95 type in NP(lo)--B cells in the following 2 weeks but brought about an increase in the number of high-affinity antibody-secreting cells (), suggesting that the B-cell compartment established was ...
may help the immune system select for B cells that produce the highest affinity antibodies to a specific antigen."If you have a high-affinity interaction,you will see higher spreading," says Batista.More antigen will thus be aggregated,which in turn will increase B cell maturation and ...
题目If you view affinity maturation as a form of rapid evolution, driven by excess reproduction and survival of the fittest, the “fittest” B cells are those that are able to ___.相关知识点: 试题来源: 解析 produce a receptor with the greatest antigen-binding strength 反馈 收藏...
Antigen specific B cells undergo a process termed affinity maturation in the germinal centers of secondary lymphoid organs where B cells with high affinity receptors are selected to mature into antibody-producing cells or to the memory B cell pool. It is known that B cell antigen receptor (BCR)...
affinity maturationpre-existing memory B cellssomatic hypermutationgerminal centerhumoral immunityMemory B cells (MBCs) formed over the individual's lifetime constitute nearly half of the circulating B cell repertoire in humans. These pre-existing MBCs dominate recall responses to their cognate antigens,...
Both IgG+and IgA+GC B cells accumulated somatic mutations, indicative of affinity maturation to a similar extent, suggesting that both types of cell were equally selected by antigen. Despite the selection in GCs, high affinity NP-specific B cells were barely detected in the IgG memory ...