manipulate stem cell populations. To support theirin vitrofindings, Androutsellis-Theotokiset al.infused DLL4 and/or FGF basic into the normal adult rat brain. While FGF basic had little effect, DLL4 stimulated the proliferation of a subset of cells that expressed early neuronal markers, but l...
To test this hypothesis in an in vivo system, we utilized the planarian Schmidtea mediterranea which contains a significant population of identifiable adult stem cells. We identified a planarian homolog of human MSH2, a MMR gene which is mutated in 38% of LS cases. The planarian Smed-msh2 ...
Newborn stem cells are younger and more flexible than adult stem cells from other sources, like bone marrow.3 IT’S A MATCH Your baby is a 100% match to their own stem cells. This may be especially important for donor-conceived individuals who don’t have access to half of their biologi...
Survival advantage of native and engineered T cells is acquired by mitochondrial transfer from mesenchymal stem cells Angela C. Court, Eliseo Parra-Crisóstomo, Pablo Castro-Córdova, Luiza Abdo, Emmanuel Arthur Albuquerque Aragão, Rocío Lorca, Fernando E. Figueroa, Martín Hernán Bonam...
is inactive, leading to a "bottleneck ". The M2 PK has to be activated by fructose 1-6 bis P its allosteric activator, whereas the M1 adult enzyme is a constitutive active form. The M2 PK bottleneck between glycolysis and the citric acid cycle is a typical feature of tumor cell ...
Glioblastoma (GBM) is by far the most common and most malignant primary adult brain tumor (World Health Organization grade IV), containing a fraction of stem-like cells that are highly tumorigenic and multipotent. Recent research has revealed that GBM stem-like cells play important roles in GBM...
Mesenchymal stem cells (MSCs) may be derived from adult bone marrow, fat, and several fetal tissues. In vitro, MSCs can be expanded and have the capacity t... KL Blanc,O Ringdén - 《Biology of Blood & Marrow Transplantation Journal of the American Society for Blood & Marrow Transplantatio...
Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics The Hoechst 33342-effluxing side population (SP) of adult mouse bone marrow (BM) contains most of the hematopoietic stem cells (HSCs). Here ...
The adult brain comprises at least two neurogenic niches harboring life-long adult neural stem cells (NSCs). An increasing number of investigations are beginning to shed light on these cells under pathological conditions and revealed a significant p...
The adult subventricular zone (SVZ) of the lateral ventricle contains neural stem cells. In rodents, these cells generate neuroblasts that migrate as chains toward the olfactory bulb along the rostral migratory stream (RMS). The neural-stem-cell niche at the ventricular wall is conserved in ...